Tandem Ubiquitin Binding Entities (TUBEs) are poly-ubiquitin capture reagents that consist of polymerized ubiquitin associated domains (UBDs). TUBEs bind to poly-ubiquitin chains with a high affinity (low nanomolar range). TUBEs are divided into 2 categories: pan-selective and chain-selective. Pan Selective TUBEs bind to all types of poly-ubiquitin linkages; whereas chain-selective TUBEs only bind to a specific type of poly-ubiquitin linkage.

As TUBEs can be conjugated to different moieties, they can be used for different research purposes. Bead-conjugated and affinity tagged TUBEs are used for purification and enrichment of poly-ubiquitinated proteins. HRP/Biotin-conjugated TUBEs are used for detection of poly-ubiquitinated proteins in Western blots; whereas fluorescence-tagged TUBEs are used for imaging purposes. In addition to that, TUBEs are incorporated in the different in vitro and cell-based assays/kits developed and commercialized by LifeSensors.

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TUBEs: Ubiquitin Affinity Matrix

All, High-throughput Plates, Kits and Plates, Molecular Glue Products, Research Kits, TUBEs: Ubiquitin Affinity Matrix

DR-0101-0035

E1-E2-E3 Assays, Kits and Plates, Research Kits, TUBEs for Detection, TUBEs: Ubiquitin Affinity Matrix

UM-0501M-1000-1

All, Magnetic TUBEs, Pan-Selective TUBEs, TUBEs: Ubiquitin Affinity Matrix

UM-0420-1000

High-throughput Plates, In Vitro Assay in PROTAC, Kits and Plates, PROTAC Tools, PROTAC Ubiquitin Assays, PROTAC Ubiquitin Plates, Research Kits, Small Molecule Modulators and PROTACs, Tools for PROTAC® R&D, TUBEs: Ubiquitin Affinity Matrix

UM-0500M-1000

All, Magnetic TUBEs, Pan-Selective TUBEs, TUBEs: Ubiquitin Affinity Matrix

UM-0501M-1000

All, Magnetic TUBEs, Pan-Selective TUBEs

UM-0406M-1000

All, M1 TUBE1, Magnetic TUBEs, TUBEs: Ubiquitin Affinity Matrix

UM-0602

All, Pan-Selective TUBEs

UM-0601

All, Pan-Selective TUBEs

SM-0101-0200

Pan-Selective TUBEs, SUMO Binding Entity (SBE)

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