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    • PROTAC & DUBTAC Drug Discovery
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      • PROTAC® Degradation Assays
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      • PROTAC Ternary Complex Assays
      • PROTAC for Cancer
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    • E3 Ubiquitin Ligases Profiling & Screening
      • Thermal Shift Assay for E3 Ligases
      • Surface Plasmon Resonance for E3 Ligases
      • Biochemical Assays (High Throughput Screening)
      • E3 TR-FRET Assay
      • E3 ELISA Assay
      • Cellular Assays (Hit Validation)
      • UbiQuant ELISA (Cellular)
      • UbiTest Substrate Validation
    • DUB Screening & Profiling
      • Ubiquitin Fluorophore Assay (Rhodamine, AMC, VME)
      • Physiological DUB Assays
      • Di-Ubiquitin IQF Assay (Patented)
      • CHOP Assay-  Ubiquitin, SUMO, ISG15 & NEDD8 (Patented)
    • SUMO-Tag Protein Expression & Purification
      • SUMOpro
      • Bacterial 
      • Mammalian
      • SUMOstar 
      • Advanced Therapeutic Applications
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      • E3 Ligase Substrate ID
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      • Ubiquitin Chain Diversity ID
    • Ligand Binding Assays
      • Thermal Shift Assays 
      • Surface Plasmon Resonance
      • Fluorescence Polarization
  • Products
    • PROTAC Tools
      • PROTAC Ubiquitin Assays
      • PROTAC Ubiquitin Plates
      • In Vitro Assay in PROTAC
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      • Autophagy Modulators
      • UPP Inhibitor Library
      • E1-E2-E3 Inhibitors
      • DUB inhibitors
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      • p97 Inhibitors
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      • Pan-Selective TUBEs
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      • Magnetic TUBEs
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      • SUMO Antibodies
    • Ubiquitin Ligases and Enzymes
      • E1 Ubiquitin Activating Enzymes
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      • MJD Family of DUBs
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    • SUMO Protein Expression System
      • Bacteria
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      • Insect cells
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    • Ubiquitin Chains and Derivatives
      • Ubiquitin and Neuro-degeneration
      • Ubiquitin Chains
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Publications

Publications
December 14, 2022

Accelerating PROTAC drug discovery: Establishing a relationship between ubiquitination and target protein degradation

Hijacking the natural mechanism of the Ubiquitin Proteasome System (UPS) is emerging as a powerful…
Isabelle Wentzel 0
Love0
Publications
December 1, 2022

Discovering Unique Ubiquitin E3 Ligase Ligands to Unlock Targeted Protein Degradation

Discovering Unique Ubiquitin E3 Ligase Ligands to Unlock Targeted Protein degradation Gauthami Jalagadugula, Alexandra Russell1+,…
Isabelle Wentzel 0
Love0
Publications
December 1, 2022

PROTACs and Molecular Glues: High-Throughput Quantitative Assays for Rationale Design

PROTACs and Molecular Glues: High-Throughput Quantitative Assays for Rationale Design Authors: Janelle Pedroza1, Kenneth Wallace1,…
Isabelle Wentzel 0
Love0
Publications
November 4, 2019

Novel Approaches to PROTAC® Drug Discovery

INTRODUCTION Proteolysis Targeting Chimeras (PROTACs) represent a promising set of drugs that target proteins without…
Bryant Darnay 0
Love8
Publications
November 8, 2018

Proteomics Discovery of Ubiquitylated Biomarkers for Neurodegenerative Disease

  ABSTRACT Ubiquitin-Proteasome system (UPS), along with chaperone mediated-autophagy (CMA) and macroautophagy, constitutes the protein…
admin 0
Love7
Publications
November 6, 2018

PROTAC Method of Action Presentation

SEE THE LIFESENSORS PRESENTATION ON NOVEL PROTAC ASSAYS HERE. PLEASE CONTACT US FOR MORE INFORMATION ON…
admin 0
Love5
Publications
July 10, 2018

New Developments in Ubiquitomics: Discovery of poly-ubiquitylated proteins by novel chain-selective TUBEs

LifeSensors Scientists Apurva Chaturvedi, Peter Foote, Li Liang, Dominic Vasturia, and Rajesh Singh recently presented…
admin 0
Love5
Publications
April 25, 2018

Deciphering the Ubiquitin Code with Poly-Ubiquitin Chain Selective Affinity Matrices

LifeSensors recently presented the work of Rajesh Singh, Cari Sagum, Jianji Chen, Apurva Chaturvedi, Peter…
admin 0
Love5
Publications
April 19, 2018

Establishing Ubiquitylation Patterns in Cells: Efficient Monitoring of Oncogenic Ubiquitylation Activity

Lifesensors recently presented the work of Peter Foote, Xialong Lu, Apurva Chaturvedi, and Rajesh Singh…
admin 0
Love4
Publications
April 19, 2018

Ubiquitin code: Accelerating the discovery of poly-ubiquitylated proteins by novel chain-selective affinity matrices

LifeSensors' Scientists Apurva Chaturvedi, Peter Foote, Dominic Vasturia, and Rajesh Singh recently presented their research…
admin 0
Love9
PROTAC IS A REGISTERED TRADEMARK OF ARVINAS OPERATIONS, INC., AND IS USED UNDER LICENSE.

LIFESENSORS

Our business development team works with customers to develop simple and cost effective work plans. We facilitate a smooth transfer of our technology, offering transfer and licensing terms that fit the needs of the client’s laboratory and organization. Our team is dedicated to providing state-of-the-art products to help put your research and development efforts into the forefront. We’ve developed non-traditional approaches and scalable discounts to bring our technology to your lab.

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271 Great Valley Parkway
Malvern, PA 19355

 
 
Phone: 610.644.8845
Fax: 610.644.8616

LifeSensors Inc.

    Menu
    • Home
    • Our Technologies
      • PROTAC & DUBTAC Drug Discovery
      • Tandem Ubiquitin Binding Entities (TUBEs)
      • Ubiquitin and Ubiquitin Chains
      • SUMO Technology & Difficult to Express Proteins
      • Molecular Glue Degraders
      • Neurodegeneration
    • R&D Services
      • PROTACs & Molecular Glues
        • PROTAC® Degradation Assays
        • PROTAC® Ubiquitination Assays
        • Target Exploration and Validation
        • Novel E3 Ligases for PROTAC ®
        • PROTAC Ternary Complex Assays
        • PROTAC for Cancer
        • PROTAC for Neuroscience
      • E3 Ubiquitin Ligases Profiling & Screening
        • Thermal Shift Assay for E3 Ligases
        • Surface Plasmon Resonance for E3 Ligases
        • Biochemical Assays (High Throughput Screening)
        • E3 TR-FRET Assay
        • E3 ELISA Assay
        • Cellular Assays (Hit Validation)
        • UbiQuant ELISA (Cellular)
        • UbiTest Substrate Validation
      • DUB Screening & Profiling
        • Ubiquitin Fluorophore Assay (Rhodamine, AMC, VME)
        • Physiological DUB Assays
        • Di-Ubiquitin IQF Assay (Patented)
        • CHOP Assay-  Ubiquitin, SUMO, ISG15 & NEDD8 (Patented)
      • SUMO-Tag Protein Expression & Purification
        • SUMOpro
        • Bacterial 
        • Mammalian
        • SUMOstar 
        • Advanced Therapeutic Applications
        • Mammalian
      • Mass Spectrometry Proteomics
        • E3 Ligase Substrate ID
        • DUB Substrate ID
        • Whole Cell Proteomics
        • Target Substrate Lysine Ubiquitination ID
        • Ubiquitin Chain Diversity ID
      • Ligand Binding Assays
        • Thermal Shift Assays 
        • Surface Plasmon Resonance
        • Fluorescence Polarization
    • Products
      • PROTAC Tools
        • PROTAC Ubiquitin Assays
        • PROTAC Ubiquitin Plates
        • In Vitro Assay in PROTAC
        • Small Molecule Modulators and PROTACs
        • Autophagy Modulators
        • UPP Inhibitor Library
        • E1-E2-E3 Inhibitors
        • DUB inhibitors
        • Proteasome Inhibitors
        • p97 Inhibitors
      • TUBEs: Ubiquitin Affinity Matrix
        • Pan-Selective TUBEs
        • K48 TUBEs HF
        • K63 TUBEs
        • Linear- M1 TUBE1
        • TUBEs for Detection
        • Magnetic TUBEs
        • Antibodies
        • Ubiquitin Antibodies
        • DUB and Ubiquitin Like Isopeptidase Antibodies
        • SUMO Antibodies
      • Ubiquitin Ligases and Enzymes
        • E1 Ubiquitin Activating Enzymes
        • E2 Ubiquitin Conjugating Enzymes
        • E3 Ubiquitin Ligases
        • Proteasomal Research Tools
        • Kits and Plates
        • E1-E2-E3 Assays
        • High-throughput Plates
        • UbiTest
        • UbiQuant
      • Deubiquitinating enzymes (DUBs)
        • USP Family of DUBs
        • UCH Family of DUBs
        • OTU Family of DUBs
        • JAMM Family of DUBs
        • MJD Family of DUBs
        • Viral and Bacterial DUBs
        • Deneddylases
        • DeSUMOylases
      • SUMO Protein Expression System
        • Bacteria
        • Mammalian cells
        • Insect cells
        • Yeast
        • SUMO Protease Enzymes
        • SUMO Protease 1
        • SUMO Protease 2
        • SUMOstar Protease
      • Ubiquitin Chains and Derivatives
        • Ubiquitin and Neuro-degeneration
        • Ubiquitin Chains
        • Ubiquitin K to R mutants
        • Ubiquitin Derivatives
        • Sumo Derivatives Chain
        • Isotopically-Labeled ubiquitin
        • CHOP2 Reporter Assays
        • IQF Diubiquitins
    • Resources
      • Discussion Forum
      • FAQs
      • PROTAC DRUG DISCOVERY
      • Mass Spec
      • SUMO
      • TUBES
    • Media
      • News
      • Press Releases
      • Publications
      • Blog Posts
    • About Us
      • About LifeSensors
      • Careers
      • Contact Us
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PROTAC

  • PROTAC Products

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    • PROTAC Compounds
    • Tools for PROTAC R&D
  • Tools for PROTAC Research and Development

    • TR-FRET in-vitro Ubiquitylation Assay
    • UbiTest
    • ELISA-based in-vitro Ubiquitylation Assay
    • UbiQuant S and AlphaLISA