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  • Home
  • Our Technologies
    • Parkinson’s Disease and Neurodegeneration
      • Phospho-ubiquitin Antibodies
      • Phospho-Ubiquitin Chains and Derivatives
      • PINK1 and Parkin Pathway Proteins
      • Neuronal DUBs and Ligases
      • Phospho-polyubiquitinated Protein Enriched Lysates
      • TUBEs: Ubiquitin Affinity Matrix
      • UbiQuant for Phospho-Polyubiquitination
    • Molecular Glue Degraders
    • PROTAC & DUBTAC Drug Discovery
      • DUBTACs
      • LYTACs
      • bioPROTACs - ​mRNA Chimeras
      • Antibody-conjugate Mediated Degradation
      • Extracellular Targeted Protein Degradation
    • Tandem Ubiquitin Binding Entities (TUBEs)
      • Pan-Selective TUBEs
      • K48 TUBEs HF
      • K63 TUBEs
      • M1 TUBEs
      • TUBEs for Detection
      • Magnetic TUBEs
    • Ubiquitin and Ubiquitin Chains
      • Ubiquitin Chains and Derivatives
      • Biotinylated Ubiquitin Chains
      • Ubiquitin K to R mutants
    • SUMO Technology and Difficult to Express Proteins
      • Polypeptide Manufacturing
      • Therapeutic Proteins, Dramatic Enhancement
      • Nanobodies and Single Chain Antibodies
      • Vaccine Manufacturing with SUMO
      • Gene Therapy: SUMO to the Rescue
  • R&D Services
    • PROTACs & Molecular Glues
      • PROTAC® Degradation Assays
      • PROTAC® Ubiquitination Assays
      • Target Exploration and Validation
      • Novel E3 Ligases for PROTAC ®
      • PROTAC Ternary Complex Assays
      • PROTAC for Cancer
      • PROTAC for Neuroscience
    • E3 Ligase Assays, Drug Screening
      • Biochemical Assays
      • E3 Substrate Ubiquitination Assays
      • Gel-Based E3 Ligase Assay
      • Novel E3 Ligases for PROTAC ®
      • Molecular Glue Degraders
      • In Vivo E3 Substrate Validation Assays
      • E3 Drugs Biophysical Assays
      • Thermal Shift Assay for E3 Ligases
      • Surface Plasmon Resonance for E3 Ligases
    • DUB Assays, Screening & Profiling
      • Ubiquitin Fluorophore Assay (Rhodamine, AMC, VME)
      • Physiological DUB Assays
      • Di-Ubiquitin IQF Assay (Patented)
      • CHOP Assay-  Ubiquitin, SUMO, ISG15 & NEDD8 (Patented)
    • SUMO-Tag Protein Expression & Purification
      • SUMOpro
      • Bacterial 
      • SUMOpro E.COLI
      • SUMOstar 
      • Advanced Therapeutic Applications
      • SUMOstar Mammalian
    • Mass Spectrometry Proteomics
      • TUBE-Based Mass Spectrometry
      • E3 Ligase Substrate ID
      • DUB Substrate ID
      • Whole Cell Proteomics
      • Target Substrate Lysine Ubiquitination ID
      • Ubiquitin Chain Diversity ID
    • Ligand Binding Assays
      • Thermal Shift Assays 
      • Surface Plasmon Resonance
      • Fluorescence Polarization
  • Products
    • Neurodegeneration Tools
      • Phospho-ubiquitin Antibodies
      • Phospho-Ubiquitin Chains and Derivatives
      • Neuronal DUBs and Ligases
      • PINK1 and Parkin Pathway Proteins
      • TUBEs: Ubiquitin Affinity Matrix
      • UbiQuant for Phospho-Polyubiquitination
    • PROTAC Tools
      • PROTAC Ubiquitin Assays
      • PROTAC Ubiquitin Plates
      • In Vitro Assay in PROTAC
      • Small Molecule Modulators and PROTACs
      • Autophagy Modulators
      • UPP Inhibitor Library
      • E1-E2-E3 Inhibitors
      • DUB inhibitors
      • Proteasome Inhibitors
      • p97 Inhibitors
    • TUBEs: Ubiquitin Affinity Matrix
      • Pan-Selective TUBEs
      • K48 TUBEs HF
      • K63 TUBEs
      • Linear- M1 TUBE1
      • TUBEs for Detection
      • Magnetic TUBEs
      • SUMO Binding Entity (SBE)
      • Antibodies
      • Ubiquitin Antibodies
      • DUB and Ubiquitin Like Isopeptidase Antibodies
      • SUMO Antibodies
    • Ubiquitin Ligases and Enzymes
      • E1 Ubiquitin Activating Enzymes
      • E2 Ubiquitin Conjugating Enzymes
      • E3 Ubiquitin Ligases
      • Proteasomal Research Tools
      • Kits and Plates
      • Colorimetric Assays
      • E1-E2-E3 Assays
      • High-throughput Plates
      • UbiTest
      • UbiQuant
    • Deubiquitinating enzymes (DUBs)
      • USP Family of DUBs
      • UCH Family of DUBs
      • OTU Family of DUBs
      • JAMM Family of DUBs
      • MJD Family of DUBs
      • Viral and Bacterial DUBs
      • Deneddylases
      • DeSUMOylases
    • SUMO Protein Expression System
      • Bacteria
      • Mammalian cells
      • Insect cells
      • Yeast
      • SUMO Protease Enzymes
      • SUMO Protease 1
      • SUMO Protease 2
      • SUMOstar Protease
    • Ubiquitin Chains and Derivatives
      • Ubiquitin and Neuro-degeneration
        • Phosphorylated Ubiquitin Chains
      • Ubiquitin Chains
      • Ubiquitin K to R mutants
      • Ubiquitin Derivatives
      • Sumo Derivatives Chain
      • Isotopically-Labeled ubiquitin
      • CHOP2 Reporter Assays
      • IQF Diubiquitins
  • Resources
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Publications

Publications
March 8, 2023

Drug Discovery with UbiTest Technology

UbiTest: Detection of polyubiquitinated proteins using TUBE based screening platforms by Gauthami S. Jalagadugula The…
Matthew Krause 0
Love1
Publications
December 14, 2022

Accelerating PROTAC drug discovery: Establishing a relationship between ubiquitination and target protein degradation

Hijacking the natural mechanism of the Ubiquitin Proteasome System (UPS) is emerging as a powerful…
Isabelle Wentzel 0
Love1
Publications
December 1, 2022

Discovering Unique Ubiquitin E3 Ligase Ligands to Unlock Targeted Protein Degradation

Discovering Unique Ubiquitin E3 Ligase Ligands to Unlock Targeted Protein degradation Gauthami Jalagadugula, Alexandra Russell1+,…
Isabelle Wentzel 0
Love1
Publications
December 1, 2022

PROTACs and Molecular Glues: High-Throughput Quantitative Assays for Rationale Design

PROTACs and Molecular Glues: High-Throughput Quantitative Assays for Rationale Design Authors: Janelle Pedroza1, Kenneth Wallace1,…
Isabelle Wentzel 0
Love1
Publications
November 4, 2019

Novel Approaches to PROTAC® Drug Discovery

INTRODUCTION Proteolysis Targeting Chimeras (PROTACs) represent a promising set of drugs that target proteins without…
Bryant Darnay 0
Love8
Publications
November 8, 2018

Proteomics Discovery of Ubiquitylated Biomarkers for Neurodegenerative Disease

  ABSTRACT Ubiquitin-Proteasome system (UPS), along with chaperone mediated-autophagy (CMA) and macroautophagy, constitutes the protein…
admin 0
Love7
Publications
November 6, 2018

PROTAC Method of Action Presentation

SEE THE LIFESENSORS PRESENTATION ON NOVEL PROTAC ASSAYS HERE. PLEASE CONTACT US FOR MORE INFORMATION ON…
admin 0
Love5
Publications
July 10, 2018

New Developments in Ubiquitomics: Discovery of poly-ubiquitylated proteins by novel chain-selective TUBEs

LifeSensors Scientists Apurva Chaturvedi, Peter Foote, Li Liang, Dominic Vasturia, and Rajesh Singh recently presented…
admin 0
Love5
Publications
April 25, 2018

Deciphering the Ubiquitin Code with Poly-Ubiquitin Chain Selective Affinity Matrices

LifeSensors recently presented the work of Rajesh Singh, Cari Sagum, Jianji Chen, Apurva Chaturvedi, Peter…
admin 0
Love5
Publications
April 19, 2018

Establishing Ubiquitylation Patterns in Cells: Efficient Monitoring of Oncogenic Ubiquitylation Activity

Lifesensors recently presented the work of Peter Foote, Xialong Lu, Apurva Chaturvedi, and Rajesh Singh…
admin 0
Love4
Publications
April 19, 2018

Ubiquitin code: Accelerating the discovery of poly-ubiquitylated proteins by novel chain-selective affinity matrices

LifeSensors' Scientists Apurva Chaturvedi, Peter Foote, Dominic Vasturia, and Rajesh Singh recently presented their research…
admin 0
Love9

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    PROTAC IS A REGISTERED TRADEMARK OF ARVINAS OPERATIONS, INC., AND IS USED UNDER LICENSE.

    LIFESENSORS

    Our business development team works with customers to develop simple and cost effective work plans. We facilitate a smooth transfer of our technology, offering transfer and licensing terms that fit the needs of the client’s laboratory and organization. Our team is dedicated to providing state-of-the-art products to help put your research and development efforts into the forefront. We’ve developed non-traditional approaches and scalable discounts to bring our technology to your lab.

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    Phone: 610.644.8845
    Fax: 610.644.8616

    LifeSensors Inc.

      Menu
      • Home
      • Our Technologies
        • Parkinson’s Disease and Neurodegeneration
          • Phospho-ubiquitin Antibodies
          • Phospho-Ubiquitin Chains and Derivatives
          • PINK1 and Parkin Pathway Proteins
          • Neuronal DUBs and Ligases
          • Phospho-polyubiquitinated Protein Enriched Lysates
          • TUBEs: Ubiquitin Affinity Matrix
          • UbiQuant for Phospho-Polyubiquitination
        • Molecular Glue Degraders
        • PROTAC & DUBTAC Drug Discovery
          • DUBTACs
          • LYTACs
          • bioPROTACs - ​mRNA Chimeras
          • Antibody-conjugate Mediated Degradation
          • Extracellular Targeted Protein Degradation
        • Tandem Ubiquitin Binding Entities (TUBEs)
          • Pan-Selective TUBEs
          • K48 TUBEs HF
          • K63 TUBEs
          • M1 TUBEs
          • TUBEs for Detection
          • Magnetic TUBEs
        • Ubiquitin and Ubiquitin Chains
          • Ubiquitin Chains and Derivatives
          • Biotinylated Ubiquitin Chains
          • Ubiquitin K to R mutants
        • SUMO Technology and Difficult to Express Proteins
          • Polypeptide Manufacturing
          • Therapeutic Proteins, Dramatic Enhancement
          • Nanobodies and Single Chain Antibodies
          • Vaccine Manufacturing with SUMO
          • Gene Therapy: SUMO to the Rescue
      • R&D Services
        • PROTACs & Molecular Glues
          • PROTAC® Degradation Assays
          • PROTAC® Ubiquitination Assays
          • Target Exploration and Validation
          • Novel E3 Ligases for PROTAC ®
          • PROTAC Ternary Complex Assays
          • PROTAC for Cancer
          • PROTAC for Neuroscience
        • E3 Ligase Assays, Drug Screening
          • Biochemical Assays
          • E3 Substrate Ubiquitination Assays
          • Gel-Based E3 Ligase Assay
          • Novel E3 Ligases for PROTAC ®
          • Molecular Glue Degraders
          • In Vivo E3 Substrate Validation Assays
          • E3 Drugs Biophysical Assays
          • Thermal Shift Assay for E3 Ligases
          • Surface Plasmon Resonance for E3 Ligases
        • DUB Assays, Screening & Profiling
          • Ubiquitin Fluorophore Assay (Rhodamine, AMC, VME)
          • Physiological DUB Assays
          • Di-Ubiquitin IQF Assay (Patented)
          • CHOP Assay-  Ubiquitin, SUMO, ISG15 & NEDD8 (Patented)
        • SUMO-Tag Protein Expression & Purification
          • SUMOpro
          • Bacterial 
          • SUMOpro E.COLI
          • SUMOstar 
          • Advanced Therapeutic Applications
          • SUMOstar Mammalian
        • Mass Spectrometry Proteomics
          • TUBE-Based Mass Spectrometry
          • E3 Ligase Substrate ID
          • DUB Substrate ID
          • Whole Cell Proteomics
          • Target Substrate Lysine Ubiquitination ID
          • Ubiquitin Chain Diversity ID
        • Ligand Binding Assays
          • Thermal Shift Assays 
          • Surface Plasmon Resonance
          • Fluorescence Polarization
      • Products
        • Neurodegeneration Tools
          • Phospho-ubiquitin Antibodies
          • Phospho-Ubiquitin Chains and Derivatives
          • Neuronal DUBs and Ligases
          • PINK1 and Parkin Pathway Proteins
          • TUBEs: Ubiquitin Affinity Matrix
          • UbiQuant for Phospho-Polyubiquitination
        • PROTAC Tools
          • PROTAC Ubiquitin Assays
          • PROTAC Ubiquitin Plates
          • In Vitro Assay in PROTAC
          • Small Molecule Modulators and PROTACs
          • Autophagy Modulators
          • UPP Inhibitor Library
          • E1-E2-E3 Inhibitors
          • DUB inhibitors
          • Proteasome Inhibitors
          • p97 Inhibitors
        • TUBEs: Ubiquitin Affinity Matrix
          • Pan-Selective TUBEs
          • K48 TUBEs HF
          • K63 TUBEs
          • Linear- M1 TUBE1
          • TUBEs for Detection
          • Magnetic TUBEs
          • SUMO Binding Entity (SBE)
          • Antibodies
          • Ubiquitin Antibodies
          • DUB and Ubiquitin Like Isopeptidase Antibodies
          • SUMO Antibodies
        • Ubiquitin Ligases and Enzymes
          • E1 Ubiquitin Activating Enzymes
          • E2 Ubiquitin Conjugating Enzymes
          • E3 Ubiquitin Ligases
          • Proteasomal Research Tools
          • Kits and Plates
          • Colorimetric Assays
          • E1-E2-E3 Assays
          • High-throughput Plates
          • UbiTest
          • UbiQuant
        • Deubiquitinating enzymes (DUBs)
          • USP Family of DUBs
          • UCH Family of DUBs
          • OTU Family of DUBs
          • JAMM Family of DUBs
          • MJD Family of DUBs
          • Viral and Bacterial DUBs
          • Deneddylases
          • DeSUMOylases
        • SUMO Protein Expression System
          • Bacteria
          • Mammalian cells
          • Insect cells
          • Yeast
          • SUMO Protease Enzymes
          • SUMO Protease 1
          • SUMO Protease 2
          • SUMOstar Protease
        • Ubiquitin Chains and Derivatives
          • Ubiquitin and Neuro-degeneration
            • Phosphorylated Ubiquitin Chains
          • Ubiquitin Chains
          • Ubiquitin K to R mutants
          • Ubiquitin Derivatives
          • Sumo Derivatives Chain
          • Isotopically-Labeled ubiquitin
          • CHOP2 Reporter Assays
          • IQF Diubiquitins
      • Resources
        • Product FAQ
        • PROTAC DRUG DISCOVERY
        • PROTACs
        • TUBEs
        • SUMO
      • Media
        • News
        • Press Releases
        • Publications
        • Blog Posts
      • About Us
        • About LifeSensors
        • Careers
        • Contact Us
      CLOSE

    PROTAC

    • PROTAC Products

      • All PROTAC Products
      • PROTAC Compounds
      • Tools for PROTAC R&D
    • Tools for PROTAC Research and Development

      • TR-FRET in-vitro Ubiquitylation Assay
      • UbiTest
      • ELISA-based in-vitro Ubiquitylation Assay
      • UbiQuant S and AlphaLISA