UM602: TUBE 2 (FLAG)


SKU: UM-0602 Categories: , Tags: , ,


Based on UBA domains known to possess a high affinity for ubiquitin, Tandem Ubiquitin Binding Entities (TUBEs) have been developed for the isolation and identification of ubiquitinated proteins. TUBEs display up to a 1000-fold increase in affinity for polyubiquitin moieties over the single ubiquitin binding associated domain (UBA). In addition, TUBEs have been demonstrated to protect polyubiquitinated proteins from both deubiquitination and proteasome-mediated degradation, allowing for the detection of relatively low abundant proteins that cannot be detected with current technologies.

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Molecular Weight 29 kDa
Physical State Liquid
Quantity 200 µg and 1 mg
Concentration Variable
Storage -80°C, avoid freeze/thaw cycles

Additional information


200 µg, 1 mg


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  • Pull down of poly-ubiquitylated proteins from cell and tissue lysates
  • Protection of poly-ubiquitylated proteins from both deubiquitylation and degradation by the proteasome


  • Up to 1000-fold higher affinity than the single UBA domain
  • Avoid overexpression of affinity-tagged ubiquitins for pull downs
  • Protect poly-ubiquitin chains without inhibitors specific to the proteasome or deubiquitylase activity
  • Replace ubiquitin specific antibodies for enrichment of poly-ubiquitylated proteins