M1 TUBE

UM406M: M1 Linear Ubiquitin TUBE (Magnetic)

$845.00

In stock

Specifications

LifeSensors has developed TUBE (Tandem Ubiquitin Binding Entity) technology for the detection, characterization and isolation of polyubiquitylated proteins. These polyubiquitinated proteins can be detected in cells and tissue extracts. Our polyubiquitin capture reagents capitalize on the linkage of multiple ubiquitin interacting motifs (UIMs) to generate reagents with a high affinity for polyubiquitin. TUBEs have 100 to 1000-fold higher affinity for polyubiquitin chains compared to monomer ubiquitin binding domains (UBDs). TUBEs both stabilize and bind to ubiquitylated proteins, serving as an indispensable tool for ubiquitologists.

Finally, our M1 linear ubiquitin TUBE has high selectivity for M1 linear-linked polyubiquitin over the more common K48- and K63-linked polyubiquitin chains, making it a powerful tool for studying the biological consequences of this ubiquitin linkage type.

This product is protected by one or more US or Foreign patents.

M1 Linear Ubiquitin TUBE Info:

Tag

Molecular Weight

Physical State

Liquid

Quantity

1 mL

Concentration

Variable

Storage

4°C

 

Need guidance or technical assistance with LifeSensors’ TUBEs? We’re happy to help! Contact our technical support team at customerservice@lifesensors.com.

 

Learn more about TUBEs here.

Additional information

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Applications

  • Isolation and enrichment of M1-polyubiquitinated proteins from cell and tissue extracts
  • Isolation of ubiquitylated proteins for proteomic studies

Benefits

  • Nanomolar dissociation constant (Kd) for M1-chains
  • 1000 to 10,000-fold preference for M1 chains over K48- or K63- chains
  • Overexpression of epitope-tagged ubiquitin for pull downs is not necessary
  • Compatible with Ni+2IMAC, streptavidin, or FLAG® -based isolation technologies, providing flexibility and specificity

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