Our Services

PROTAC® Drug Discovery

PROTAC compounds, plate-based in vitro and cellular HTS assays

Mass Spec Ubiquitin Proteomics

Global substrate ID, TUBE-based affinity matrices, Tandem mass spec, and custom assays

E3 Ligase Screening & Profiling

Plate-based assays, best E2 identification, ubiquitin chain identification, compound library screening, custom assays

DUB Screening & Profiling

Plate-based assays, compound library screening, ubiquitin chain selectivity, custom assays

Protein Expression & Purification

SUMO-tag system for both prokaryotic and eukaryotic cells to maximize protein expression

Biomarker Assay Development

Assay development  and biomarker identification for drug optimization

Biophysical Assays

Surface Plasmon Resonance (SPR); Thermal Shift Assay (TSA); Protein-Protein interactions; Protein-ligand interactions

Our Products

TUBEs: Ubiquitin Affinity Matrix

Pan-selective TUBEs, SUMO traps, K48-, K63- and linear M1 selective TUBEs

Kits and Plates

PROTAC® Assay Plate; UbiTest: substrate ubiquitylation; UbiQuant/S: high-throughput ubiquitylation

Protein Expression Systems

SUMO/SUMOpro/SUMOstar maximizes solubility and yield of your protein in any host

Ubiquitins and Chains

Ubiquitin fluorescent probes, lysine mutants, and polyubiquitin chains, Diubiquitin IQFs, CHOP ubiquitin reporter

Ubiquitin Pathway Enzymes

E1 and E2 enzymes, E3 ligases, DUBs,
Proteasomal tools

Antibodies & Inhibitors

Top-rated VU-1 antibody, ubiquitin antibodies, Ubiquitin pathway inhibitors and antibodies

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.