UM201-1MG Anti-Ub TUBE 1, His6

UM102: TUBE 2 (GST)

$375.00$1,105.00

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Specifications

Based on UBA domains known to possess an affinity for ubiquitin, Tandem Ubiquitin Binding Entities (TUBEs) have been developed for the isolation and identification of ubiquitinated proteins. TUBEs display up to a 1000-fold increase in affinity for polyubiquitin moieties over the single ubiquitin binding associated domain (UBA). In addition, TUBEs have been shown to have a protective effect on polyubiquitinated proteins from both deubiquitination and proteasome-mediated degradation, allowing for detection of relatively low abundance proteins that cannot be detected with current technologies.

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Info

 

Tag

GST

Molecular Weight

56 kDa

Physical State

Liquid

Quantity

200 µg and 1 mg

Concentration

Variable

Storage

-80°C, avoid freeze/thaw cycles

 

Additional information

Weight

200 µg, 1 mg

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  • Pull down of poly-ubiquitylated proteins from cell and tissue lysates
  • Protection of poly-ubiquitylated proteins from both deubiquitylation and degradation by the proteasome

 

Benefits

  • Up to 1000-fold higher affinity than the single UBA domain
  • Avoid overexpression of affinity-tagged ubiquitins for pull downs
  • Protect poly-ubiquitin chains without inhibitors specific to the proteasome or deubiquitylase activity
  • Replace ubiquitin specific antibodies for enrichment of poly-ubiquitylated proteins