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    • Parkinson’s Disease and Neurodegeneration
      • Phospho-ubiquitin Antibodies
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      • PINK1 and Parkin Pathway Proteins
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      • Phospho-polyubiquitinated Protein Enriched Lysates
      • TUBEs: Ubiquitin Affinity Matrix
      • UbiQuant for Phospho-Polyubiquitination
    • Molecular Glue Degraders
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    • E3 Ligase Assays, Drug Screening
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      • Novel E3 Ligases for PROTAC ®
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      • E3 Drugs Biophysical Assays
      • Thermal Shift Assay for E3 Ligases
      • Surface Plasmon Resonance for E3 Ligases
    • DUB Assays, Screening & Profiling
      • Ubiquitin Fluorophore Assay (Rhodamine, AMC, VME)
      • Physiological DUB Assays
      • Di-Ubiquitin IQF Assay (Patented)
      • CHOP Assay-  Ubiquitin, SUMO, ISG15 & NEDD8 (Patented)
    • SUMO-Tag Protein Expression & Purification
      • SUMOpro
      • Bacterial 
      • SUMOpro E.COLI
      • SUMOstar 
      • Advanced Therapeutic Applications
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      • TUBE-Based Mass Spectrometry
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    • Ligand Binding Assays
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      • Surface Plasmon Resonance
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  • Products
    • Neurodegeneration Tools
      • Phospho-ubiquitin Antibodies
      • Phospho-Ubiquitin Chains and Derivatives
      • Neuronal DUBs and Ligases
      • PINK1 and Parkin Pathway Proteins
      • TUBEs: Ubiquitin Affinity Matrix
      • UbiQuant for Phospho-Polyubiquitination
    • PROTAC Tools
      • PROTAC Ubiquitin Assays
      • PROTAC Ubiquitin Plates
      • In Vitro Assay in PROTAC
      • Small Molecule Modulators and PROTACs
      • Autophagy Modulators
      • UPP Inhibitor Library
      • E1-E2-E3 Inhibitors
      • DUB inhibitors
      • Proteasome Inhibitors
      • p97 Inhibitors
    • TUBEs: Ubiquitin Affinity Matrix
      • Pan-Selective TUBEs
      • K48 TUBEs HF
      • K63 TUBEs
      • Linear- M1 TUBE1
      • TUBEs for Detection
      • Magnetic TUBEs
      • SUMO Binding Entity (SBE)
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    • Ubiquitin Ligases and Enzymes
      • E1 Ubiquitin Activating Enzymes
      • E2 Ubiquitin Conjugating Enzymes
      • E3 Ubiquitin Ligases
      • Proteasomal Research Tools
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      • High-throughput Plates
      • UbiTest
      • UbiQuant
    • Deubiquitinating enzymes (DUBs)
      • USP Family of DUBs
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    • Ubiquitin Chains and Derivatives
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        • Phosphorylated Ubiquitin Chains
      • Ubiquitin Chains
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Blog Posts

BlogEducation
January 17, 2024

PINK PARKIN Signaling Dysfunction Serves as a Breakthrough in Neurodegenerative Research and Biomarker

By: Derrick Padykula and Isabelle Wentzel Hallmark of Neurodegeneration  Diving into the complex world of neurodegeneration…
Isabelle Wentzel 0
Love0
BlogEducation
December 14, 2023

Unveiling the Power of TUBEs: Revolutionizing Ubiquitin Research

By: Derrick Padykula Ubiquitination, a ubiquitous cellular process, involves attaching ubiquitin to target proteins, influencing…
Isabelle Wentzel 0
Love0
BlogEducation
March 8, 2023

Tragedy to Transformation – Molecular Glue Sparks the Field of Targeted Protein Degradation

By: Isabelle Wentzel   Devastating Origins In the late 1950s and early 1960s, pregnant women…
Isabelle Wentzel 0
Love0
BlogEducation
September 8, 2022

Profiling E3 ligase compounds and the Implications in Drug Discovery

By: Abdul Haseeb, Ph.D.   Drugging the Undruggable Tremendous progress in genomics, transcriptomics and proteomics…
Matthew Krause 0
Love0
EducationPress Releases
September 1, 2022

Accelerating PROTAC drug discovery: Establishing a Relationship Between Ubiquitination and Target Protein Degradation

MALVERN, Pa., SEP 1, 2022 – LifeSensors Inc., a Biotech and Drug Discovery Company focused…
Matthew Krause 0
Love2
BlogEducation
February 2, 2022

PROTAC Drug Discovery January 2022 Webinar

PROTAC Drug Discovery Webinar January 2022
Sterling Jones 0
Love0

Drug Discovery Picks Up the Pace, Stays on Target

https://www.genengnews.com/topics/drug-discovery/drug-discovery-picks-up-the-pace-stays-on-target/
BlogEducation
August 12, 2021

The Power of PROTACs

By: Rebekah Varghese, Derrick Padykula, & Jacob Huang All the FDA-approved drugs combined interact with…
Sterling Jones 0
Love0
BlogEducation
July 22, 2021

Plunging into the Plight of Parkinson’s Disease

By: Rebekah Varghese and Derrick Padykula Parkinson’s Disease (PD) is the second most common neurodegenerative…
Sterling Jones 0
Love0
Schematic of the UPS
BlogEducation
March 1, 2021

Ubiquitin-Proteasome System

The Ubiquitin-Proteasome System: An Overview   The Ubiquitin-Proteasome system (UPS) is a highly complex, temporally…
Myra Zerr 0
Love0
BlogEducation
November 23, 2020

The Biomarkers of Alzheimer’s Disease

November is a month dedicated to the awareness of Alzheimer’s Disease, an age-related illness of…
Myra Zerr 0
Love0
Education
October 31, 2019

Autophagy

Autophagy Autophagy is a process by which eukaryotic cells degrade and recycle proteins and organelles…
Bryant Darnay 0
Love1
Education
October 31, 2019

Ubiquitin and Neuroscience

Ubiquitin and Neuroscience Neurodegenerative diseases are often characterized by excessive or dysfunctional proteins and protein…
Bryant Darnay 0
Love1
Education
May 17, 2019

Lewy Body Dementia – Hiding in Plain Sight

Lewy Body Dementia (LBD) is a debilitating neurodegenerative disease that is increasingly becoming a public…
admin 0
Love9
Education
August 10, 2018

PARKINSON’S DISEASE: BIOMARKERS OF EARLY DISCOVERY

By: Mark Tingey, Katelyn Roberts, and Meredith Paterson Parkinson’s disease is often referred to as…
admin 0
Love1
Education
July 10, 2018

Protein Profiles: UCHL1

UCHL1 The protein encoded by UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a thiol protease belonging…
admin 0
Love6
Education
July 10, 2018

Protein Profiles: USP14

USP14 USP14 is a ubiquitin specific protease that associates with the proteasome. This association with…
admin 0
Love6
Education
July 10, 2018

Protein Profiles: USP8

USP8 USP8 is associated with endosomal trafficking, it is not clear that this isopeptidase is…
admin 0
Love6
Education
July 10, 2018

Protein Profiles: E6-AP

E6-AP E6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the…
admin 0
Love6
Education
July 10, 2018

Protein Profiles: ITCH

ITCH ITCH is a HECT E3, which influences immunity, the skin, and plays a role…
admin 0
Love6
Education
July 10, 2018

Protein Profiles: Nedd4

NEDD4 Nedd4 is an inner membrane bound HECT E3 that promotes endocytosis of sodium channels…
admin 0
Love6
Education
July 10, 2018

Protein Profiles: CHIP

CHIP CHIP is an E3 that coordinates with Ataxin3 to mark misfolded chaperone proteins for…
admin 0
Love6
Education
June 18, 2018

Protein Profiles: Tau Proteins

TAU PROTEINS PDB ID: 5D2V Within healthy neurons, tau proteins are responsible for stabilizing microtubules…
admin 0
Love6
Education
June 18, 2018

Protein Profiles: Parkin

PARKIN PDB ID: 5C1Z Parkin is an E3 ligase, which ubiquitinylates proteins for degradation within…
admin 0
Love6
1 2 Next »

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      Menu
      • Home
      • Our Technologies
        • Parkinson’s Disease and Neurodegeneration
          • Phospho-ubiquitin Antibodies
          • Phospho-Ubiquitin Chains and Derivatives
          • PINK1 and Parkin Pathway Proteins
          • Neuronal DUBs and Ligases
          • Phospho-polyubiquitinated Protein Enriched Lysates
          • TUBEs: Ubiquitin Affinity Matrix
          • UbiQuant for Phospho-Polyubiquitination
        • Molecular Glue Degraders
        • PROTAC & DUBTAC Drug Discovery
          • DUBTACs
          • LYTACs
          • bioPROTACs - ​mRNA Chimeras
          • Antibody-conjugate Mediated Degradation
          • Extracellular Targeted Protein Degradation
        • Tandem Ubiquitin Binding Entities (TUBEs)
          • Pan-Selective TUBEs
          • K48 TUBEs HF
          • K63 TUBEs
          • M1 TUBEs
          • TUBEs for Detection
          • Magnetic TUBEs
        • Ubiquitin and Ubiquitin Chains
          • Ubiquitin Chains and Derivatives
          • Biotinylated Ubiquitin Chains
          • Ubiquitin K to R mutants
        • SUMO Technology and Difficult to Express Proteins
          • Polypeptide Manufacturing
          • Therapeutic Proteins, Dramatic Enhancement
          • Nanobodies and Single Chain Antibodies
          • Vaccine Manufacturing with SUMO
          • Gene Therapy: SUMO to the Rescue
      • R&D Services
        • PROTACs & Molecular Glues
          • PROTAC® Degradation Assays
          • PROTAC® Ubiquitination Assays
          • Target Exploration and Validation
          • Novel E3 Ligases for PROTAC ®
          • PROTAC Ternary Complex Assays
          • PROTAC for Cancer
          • PROTAC for Neuroscience
        • E3 Ligase Assays, Drug Screening
          • Biochemical Assays
          • E3 Substrate Ubiquitination Assays
          • Gel-Based E3 Ligase Assay
          • Novel E3 Ligases for PROTAC ®
          • Molecular Glue Degraders
          • In Vivo E3 Substrate Validation Assays
          • E3 Drugs Biophysical Assays
          • Thermal Shift Assay for E3 Ligases
          • Surface Plasmon Resonance for E3 Ligases
        • DUB Assays, Screening & Profiling
          • Ubiquitin Fluorophore Assay (Rhodamine, AMC, VME)
          • Physiological DUB Assays
          • Di-Ubiquitin IQF Assay (Patented)
          • CHOP Assay-  Ubiquitin, SUMO, ISG15 & NEDD8 (Patented)
        • SUMO-Tag Protein Expression & Purification
          • SUMOpro
          • Bacterial 
          • SUMOpro E.COLI
          • SUMOstar 
          • Advanced Therapeutic Applications
          • SUMOstar Mammalian
        • Mass Spectrometry Proteomics
          • TUBE-Based Mass Spectrometry
          • E3 Ligase Substrate ID
          • DUB Substrate ID
          • Whole Cell Proteomics
          • Target Substrate Lysine Ubiquitination ID
          • Ubiquitin Chain Diversity ID
        • Ligand Binding Assays
          • Thermal Shift Assays 
          • Surface Plasmon Resonance
          • Fluorescence Polarization
      • Products
        • Neurodegeneration Tools
          • Phospho-ubiquitin Antibodies
          • Phospho-Ubiquitin Chains and Derivatives
          • Neuronal DUBs and Ligases
          • PINK1 and Parkin Pathway Proteins
          • TUBEs: Ubiquitin Affinity Matrix
          • UbiQuant for Phospho-Polyubiquitination
        • PROTAC Tools
          • PROTAC Ubiquitin Assays
          • PROTAC Ubiquitin Plates
          • In Vitro Assay in PROTAC
          • Small Molecule Modulators and PROTACs
          • Autophagy Modulators
          • UPP Inhibitor Library
          • E1-E2-E3 Inhibitors
          • DUB inhibitors
          • Proteasome Inhibitors
          • p97 Inhibitors
        • TUBEs: Ubiquitin Affinity Matrix
          • Pan-Selective TUBEs
          • K48 TUBEs HF
          • K63 TUBEs
          • Linear- M1 TUBE1
          • TUBEs for Detection
          • Magnetic TUBEs
          • SUMO Binding Entity (SBE)
          • Antibodies
          • Ubiquitin Antibodies
          • DUB and Ubiquitin Like Isopeptidase Antibodies
          • SUMO Antibodies
        • Ubiquitin Ligases and Enzymes
          • E1 Ubiquitin Activating Enzymes
          • E2 Ubiquitin Conjugating Enzymes
          • E3 Ubiquitin Ligases
          • Proteasomal Research Tools
          • Kits and Plates
          • Colorimetric Assays
          • E1-E2-E3 Assays
          • High-throughput Plates
          • UbiTest
          • UbiQuant
        • Deubiquitinating enzymes (DUBs)
          • USP Family of DUBs
          • UCH Family of DUBs
          • OTU Family of DUBs
          • JAMM Family of DUBs
          • MJD Family of DUBs
          • Viral and Bacterial DUBs
          • Deneddylases
          • DeSUMOylases
        • SUMO Protein Expression System
          • Bacteria
          • Mammalian cells
          • Insect cells
          • Yeast
          • SUMO Protease Enzymes
          • SUMO Protease 1
          • SUMO Protease 2
          • SUMOstar Protease
        • Ubiquitin Chains and Derivatives
          • Ubiquitin and Neuro-degeneration
            • Phosphorylated Ubiquitin Chains
          • Ubiquitin Chains
          • Ubiquitin K to R mutants
          • Ubiquitin Derivatives
          • Sumo Derivatives Chain
          • Isotopically-Labeled ubiquitin
          • CHOP2 Reporter Assays
          • IQF Diubiquitins
      • Resources
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    PROTAC

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      • Tools for PROTAC R&D
    • Tools for PROTAC Research and Development

      • TR-FRET in-vitro Ubiquitylation Assay
      • UbiTest
      • ELISA-based in-vitro Ubiquitylation Assay
      • UbiQuant S and AlphaLISA