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UM101: TUBE 1 (GST)

LifeSensors UM101 is a pan-ubiquitin antibody used for detecting ubiquitin and ubiquitinated proteins in research, supporting studies in protein degradation and signaling.

$633.00$2,069.00

Applications

  • Pull down of poly-ubiquitylated proteins from cell and tissue lysates
  • Protection of poly-ubiquitylated proteins from both deubiquitylation and degradation by the proteasome

Benefits

  • Up to 1000-fold higher affinity than the single UBA domain
  • Avoid overexpression of affinity-tagged ubiquitins for pull downs
  • Protect poly-ubiquitin chains without inhibitors specific to the proteasome or deubiquitylase activity
  • Replace ubiquitin specific antibodies for enrichment of poly-ubiquitylated proteins

 

Based on UBA domains known to possess a high affinity for ubiquitin, Tandem Ubiquitin Binding Entities (TUBEs) have been developed for the isolation and identification of ubiquitinated proteins. TUBEs display up to a 1000-fold increase in affinity for polyubiquitin moieties over the single ubiquitin binding associated domain (UBA). In addition, TUBEs have been demonstrated to protect polyubiquitinated proteins from both deubiquitination and proteasome-mediated degradation, allowing for the detection of relatively low abundant proteins that cannot be detected with current technologies. This product is protected by one or more US or Foreign patents. Please read the Limited Use Label License to learn more. By purchasing this product, the purchaser agrees to comply with these terms.

Info

Tag GST
Molecular Weight 56 kDa
Physical State Liquid
Quantity 200 µg and 1 mg
Concentration Variable
Storage -80°C, avoid freeze/thaw cycles

Applications

  • Pull down of poly-ubiquitylated proteins from cell and tissue lysates
  • Protection of poly-ubiquitylated proteins from both deubiquitylation and degradation by the proteasome

Benefits

  • Up to 1000-fold higher affinity than the single UBA domain
  • Avoid overexpression of affinity-tagged ubiquitins for pull downs
  • Protect poly-ubiquitin chains without inhibitors specific to the proteasome or deubiquitylase activity
  • Replace ubiquitin specific antibodies for enrichment of poly-ubiquitylated proteins

 

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