UM101: TUBE 1 (GST)

LifeSensors UM101 is a pan-ubiquitin antibody used for detecting ubiquitin and ubiquitinated proteins in research, supporting studies in protein degradation and signaling.

$633.00 – $2,069.00

SKU UM-0101 Categories Pan-Selective TUBEs, TUBEs: Ubiquitin Affinity Matrix Tags Pan-selective, Pull down, Tandem Ubiquitin Binding entities

Product Advantages

Applications

Pull down of poly-ubiquitylated proteins from cell and tissue lysates

Protection of poly-ubiquitylated proteins from both deubiquitylation and degradation by the proteasome

Benefits

Up to 1000-fold higher affinity than the single UBA domain

Avoid overexpression of affinity-tagged ubiquitins for pull downs

Protect poly-ubiquitin chains without inhibitors specific to the proteasome or deubiquitylase activity

Replace ubiquitin specific antibodies for enrichment of poly-ubiquitylated proteins

Based on UBA domains known to possess a high affinity for ubiquitin, Tandem Ubiquitin Binding Entities (TUBEs) have been developed for the isolation and identification of ubiquitinated proteins. TUBEs display up to a 1000-fold increase in affinity for polyubiquitin moieties over the single ubiquitin binding associated domain (UBA). In addition, TUBEs have been demonstrated to protect polyubiquitinated proteins from both deubiquitination and proteasome-mediated degradation, allowing for the detection of relatively low abundant proteins that cannot be detected with current technologies. This product is protected by one or more US or Foreign patents. Please read the Limited Use Label License to learn more. By purchasing this product, the purchaser agrees to comply with these terms.

Info

Tag	GST
Molecular Weight	56 kDa
Physical State	Liquid
Quantity	200 µg and 1 mg
Concentration	Variable
Storage	-80°C, avoid freeze/thaw cycles