DUB Substrate ID
DUB Substrate ID
The Ubiquitin Proteasome System (UPS) controls the principal functions of almost all the cellular proteins of human cells and failures in this system often contribute directly or indirectly to the pathogenesis of many diseases, including cancer, inflammation, and neurodegeneration. There are ~100 Deubiquitinases (DUBs) encoded in human genome and the functions of most of these DUBs remain unknown. Identification of substrates of individual DUBs is an essential step to unravel cellular functions of DUBs. Lifesensors can help you identify the substrates of your preferred DUBs.
Advantages of Choosing LifeSensors for your Molecular Glue Drug Discovery
- In vitro and in cell assays to identify DUB substrates
- Human protein array enables identification of direct deubiquitination targets
- Substrate Trapping and Proteomic analysis to identify endogenous substrates
- Validation of substrates in orthogonal assays
