SI420-50µg hSUMO1-AMC

SM101: Biotin SUMO protein capture reagent

$285.00

In stock

Specifications

Small ubiquitin-like modifier (SUMO) proteins are a family of proteins that have a similar structure with ubiquitin. There are four SUMO genes in human genome. SUMO2 and SUMO3 are highly similar (97% identical), while SUMO1 is quite distinct from other members. SUMO4 contains a specific proline90 residue, which prevents it from being processed by SUMO protease. SUMOylation is a reversible post-translational modification that covalently attaches SUMO to target proteins. SUMOylation regulates many critical cellular processes, including replication, cell-cycle, protein transport and DNA repair. SUMO is essential for almost all the eukaryotes, and deregulation of SUMOylation leads to several diseases such as cancer and neurodegenerative diseases. Therefore, it is critical to understand the regulation of SUMO. Here, the team in LifeSensors have developed a small peptide, SUMO protein capture reagent, which specifically recognizes SUMO proteins.  This reagent is designed for detection, characterization, and isolation of SUMOylated proteins from cells and tissue extracts.

Info

Tag 

Biotin 

Molecular Weight 

5889 Da 

Physical State 

Liquid 

Quantity 

200 µg 

Concentration 

5 mg/mL 

Storage 

-20°C. Avoid freeze/thaw cycles 

Additional information

SKU

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Applications

  • The biotin SUMO protein capture reagent is able to specifically detect SUMOylated protein in combination with HRP-Conjugated Streptavidin.
  • The biotin SUMO protein capture reagent could be used for isolating SUMOylated protein from cell samples with Streptavidin resin.

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