By: Derrick Padykula and Isabelle Wentzel Hallmark of Neurodegeneration Diving into the complex world of neurodegeneration unveils the long road marked by the gradual decline of neuronal cells, ultimately leading to cell death. In Parkinson’s disease (PD) and Alzheimer’s disease (AD), the accumulation of aggregated proteins and dysfunctional mitochondria is what contributes to the demise of […]
By: Derrick Padykula Ubiquitination, a ubiquitous cellular process, involves attaching ubiquitin to target proteins, influencing crucial cellular functions such as degradation, cell signaling, apoptosis, protein processing, immune response, and DNA repair. The specific ubiquitin chain type, whether M1, K6, K11, K27, K29, K33, K48, or K63-linked, dictates the downstream processing of the target protein. Delving […]
MALVERN, Pa., October 26, 2023 — LifeSensors, Inc., a leading innovator in protein degradation technologies, has been invited to speak at the 6th Annual Targeted Protein Degradation Summit 2023 in Boston, Massachusetts. The event will take place from October 30-November 2 at Westin Copley Place, Boston. LifeSensors will be exhibiting, and Dr. Karteek Kadimisetty will […]
[Malvern, PA, October 18, 2023] — LifeSensors Inc., a biotech company targeting the ubiquitin proteasome system for drug discovery and diagnostic markers, has received funding from the National Institute on Aging and National Institute of General Medicine. The funding, to the tune of $5.53 million, provides for the development of PROTAC drug discovery technologies. PROTACs […]
MALVERN, Pa., SEP 21, 2023 — LifeSensors Inc., a Biotech and Drug Discovery Company focused on PROTAC, molecular glue drug discovery and neurodegeneration diagnostics has been invited to speak at the 21st annual Discovery on Target 2023. Dr. Karteek Kadimisetty, LifeSensors’ Director of Research and Development will be presenting new information, and answering questions regarding PROTACs, […]
MALVERN, PA., May 30, 2023 — LifeSensors Inc., a Biotech and Drug Discovery Company focused on PROTACs, molecular glues, and neurodegeneration diagnostics will disclose direct methods to detect PROTAC & molecular glue mediated ubiquitination drug targets at BIO this year in Boston, MA, June 5-8, 2023. Current methods of PROTAC & Molecular Glue discovery are time consuming, […]
By: Isabelle Wentzel Devastating Origins In the late 1950s and early 1960s, pregnant women who experienced nausea and morning sickness were prescribed thalidomide, a sedative drug meant to treat these symptoms. In early 1960, it quickly became evident that there was a link between the thousands of infants born with severe birth defects and […]
UbiTest: Detection of polyubiquitinated proteins using TUBE based screening platforms by Gauthami S. Jalagadugula The ubiquitin proteasome system (UPS) is a highly regulated mechanism that controls many cellular processes through protein ubiquitination and degradation. Ubiquitin is conjugated via its C-terminus to lysine residues on the target proteins as a monomer or as a polymer chain. […]
Hijacking the natural mechanism of the Ubiquitin Proteasome System (UPS) is emerging as a powerful medium in drug discovery through which Dr. Kadimisetty uses “TUBEs” as ubiquitin-binding entities to monitor PROTAC-mediated poly-ubiquitination of target proteins. The technology described wherein is a direct way to evaluate and discover PROTAC and molecular glue targets for use in […]
Discovering Unique Ubiquitin E3 Ligase Ligands to Unlock Targeted Protein degradation Gauthami Jalagadugula, Alexandra Russell1+, Kenneth Wallace1+, Janelle Pedroza and Abdul Haseeb1 * Introduction PROteolytic TArgeting Chimeras (PROTACs) have emerged as new class of drugs to target “undruggable” proteome. The human genome encodes ~ 600 E3 ligases that differentially expressed across various tissues. Only a […]
PROTACs and Molecular Glues: High-Throughput Quantitative Assays for Rationale Design Authors: Janelle Pedroza1, Kenneth Wallace1, Derrick Padykula, Alexandra Russell1, and Karteek Kadimisetty*1 Introduction PROTACs have emerged as new class of drugs that can target the “undruggable” proteome by hijacking the ubiquitin proteasome system. Traditional methods like western blotting and reporter gene assays are prone to […]
By: Abdul Haseeb, Ph.D. Drugging the Undruggable Tremendous progress in genomics, transcriptomics and proteomics has led to the discovery of thousands of new drivers of disease, but drug discovery is still catching up to these new potential drug targets because most of these new players are intractable to traditional pharmacological targeting. Traditional small molecule […]
MALVERN, Pa., SEP 1, 2022 – LifeSensors Inc., a Biotech and Drug Discovery Company focused on PROTAC, molecular glues, and neurodegeneration diagnostics, is pleased to announce that Lifesensors has published a seminal paper: Accelerating PROTAC drug discovery: Establishing a relationship between ubiquitination and target protein degradation. This paper is published in the Biochemical and Biophysical […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text] LifeSensors is Attending ASCB | EMBO Cell Bio 2022 MALVERN, PA., AUG 30, 2022 — LifeSensors Inc., a Biotech and Drug Discovery Company focused on PROTACs, molecular glues, and neurodegeneration diagnostics will […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text] LifeSensors Invited to Speak at the Industry’s Preeminent 20th Annual Discovery on Target Conference MALVERN, Pa., AUG 30, 2022 — LifeSensors Inc., a Biotech and Drug Discovery Company focused on PROTAC, molecular […]
LifeSensors Attending the 5th Annual Targeted Protein Degradation Summit MALVERN, PA., AUG 30, 2022 — LifeSensors Inc., a Biotech and Drug Discovery Company focused on PROTAC, Molecular Glues, and neurodegeneration diagnostics has been invited to speak at 5th Targeted Protein Degradation Summit in Boston MA. Dr. Karteek Kadimisetty, LifeSensors’ Director of Research and Development will be presenting […]
PROTAC Drug Discovery Webinar January 2022
By: Rebekah Varghese, Derrick Padykula, & Jacob Huang All the FDA-approved drugs combined interact with only 2% of the proteins found in human cells, according to Dr. Brent Stockwell, a professor at the Howard Hughes Medical Institute. It is truly disturbing to realize that many of the most devastating diseases, such as cancer, autoimmune disease, […]
By: Rebekah Varghese and Derrick Padykula Parkinson’s Disease (PD) is the second most common neurodegenerative disease, affecting 1-2% of the population. Now, when you consider the world’s population to be upwards of 7 billion, you realize that more than 7 million people are suffering from PD today. One of these PD patients could be your […]
The Ubiquitin-Proteasome System: An Overview The Ubiquitin-Proteasome system (UPS) is a highly complex, temporally controlled and conserved pathway that plays a major role in a myriad on cellular functions. From cellular differentiation to cell death, the UPS has a large hand in determining the fate of cells and proteins. It is important to understand […]
November is a month dedicated to the awareness of Alzheimer’s Disease, an age-related illness of the brain that causes cognitive and physiological decline. LifeSensors has great appreciation for our fellow researchers who are dedicating their lives to fighting back against this condition. We remember our loved ones who we have lost to Alzheimer’s Disease, and […]
DTE proteins, or ‘difficult-to-express’ proteins are a common hurdle for researchers in the lab. Due to difficulty with correct protein folding and general protein synthesis success, coronavirus proteins find themselves with the deserved label of DTE proteins. The first coronavirus pandemic, SARS-CoV, had many researchers struggling with the synthesis of many of its proteins including […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text]LifeSensors is happy to say we’re growing! We’ve always been one to say more the merrier, and now we truly are. With Axxora, we can offer near-complete global availability to those who were […]
FDA Provisional Approval LifeSensors is proud to announce its provisional FDA approval for our COVID-19 IgG ELISA Detection Kit to address the critical need for COVID-19 diagnostics through serological testing. Establishing the infection history of SARS-CoV-2 individuals will assist identifying those likely to transmit the disease, effectively halting the spread of the virus. The COVID-19 […]
IgG & Total Antibody Kit At LifeSensors, we value and believe that a reliable and affordable test against COVID-19 can protect patients and healthcare professionals from around the world by detecting antibodies, from both past and present infections. COVID-19 antibody kits have the capability of doing just that. With that being said, we have launched […]
LifeSensors, Inc is pleased to announce it has been granted CLIA certification in light of the COVID-19 pandemic. With this new certification, LifeSensors will be able to aid with the heavy influx of COVID-19 test processing throughout the country. Armed with high-performance testing technologies, as well as highly trained scientific professionals, the Malvern biotechnology corporation […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text] INTRODUCTION Proteolysis Targeting Chimeras (PROTACs) represent a promising set of drugs that target proteins without an inherent enzymatic activity for proteasomal degradation. Despite all the efforts being invested in PROTAC discovery, progress […]
Autophagy Autophagy is a process by which eukaryotic cells degrade and recycle proteins and organelles using intracellular lysosomes. Malfunctions in autophagy have been shown to induce many diseases including cancer, neurodegeneration, diabetes, autoimmunity, and cardiovascular diseases. Autophagy and Ubiquitin Autophagy can be induced by many intra- and extra-cellular stress conditions such as endoplasmic reticulum stress, […]
Ubiquitin and Neuroscience Neurodegenerative diseases are often characterized by excessive or dysfunctional proteins and protein aggregates, which induce specific pathological conditions. The ubiquitin proteasome system and autophagy play key roles in the regulation of protein homeostasis in neurons. Accordingly, understanding enzyme dysfunction in the ubiquitin proteasome system and autophagy is critical to understanding and ultimately […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text]LifeSensors is a proud sponsor of the EMBO Ubiquitin Workshop in Cavtat, Croatia from September 13-17, 2019! This workshop is important to the Ubiquitin community to inspire further progress and collaboration. [/vc_column_text][/vc_column][/vc_row]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text] LIFESENSORS ATTENDS BIO CONVENTION 2019 IN PHILADELPHIA The Bio International Convention will be in Philadelphia from June 3-6, 2019. More than 16,000 biotech and pharmaceutical leaders will attend and network to explore new opportunities […]
Lewy Body Dementia (LBD) is a debilitating neurodegenerative disease that is increasingly becoming a public health concern. “In Lewy body dementia, alpha-synuclein forms into clumps inside neurons, starting in areas of the brain that control aspects of memory and movement. This process causes neurons to work less effectively and, eventually, to die.” Currently, 1 in […]
The Cold Spring Harbor Laboratory will be hosting a conference on the Ubiquitin Proteasome System (UPS) and associated Diseases April 23rd-27th. LifeSensors will be presenting on our most recent developments in ubiquitin technology that will impact the field of ubiquitin research. The list of attendees already features many of the leaders in the field. We […]
LifeSensors has spent years supporting the drug discovery efforts in Ubiquitin Proteasome System (UPS) research. We are excited to see this growing area of research gain more attention through conferences like this. We believe PROTACs and other modulators of the UPS will make profound impacts in the clinic, on a variety of “undruggable” targets. LifeSensors […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text] ABSTRACT Ubiquitin-Proteasome system (UPS), along with chaperone mediated-autophagy (CMA) and macroautophagy, constitutes the protein quality control system of the cell. The failure of these systems is particularly difficult to overcome in […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text]SEE THE LIFESENSORS PRESENTATION ON NOVEL PROTAC ASSAYS HERE. PLEASE CONTACT US FOR MORE INFORMATION ON THIS EXCITING TECHNOLOGY- BD@LIFESENSORS.COM[/vc_column_text][/vc_column][/vc_row]
By: Mark Tingey, Katelyn Roberts, and Meredith Paterson Parkinson’s disease is often referred to as a silent disease. It often begins in very innocuous ways, small ticks and behaviors that are almost imperceptible. This is how it began with Alan Alda. In a recent interview, he explained that he first suspected something was amiss when […]
LIFESENSORS TO SPONSOR DISCOVERY ON TARGET To help further scientific advancement in the field of ubiquitin, LifeSensors has partnered with CHI to assist with their Discovery on Target conference this September in Boston. This event will provide unique insight into the state of the field, and how we as scientists can work together to resolve […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text] LifeSensors Scientists Apurva Chaturvedi, Peter Foote, Li Liang, Dominic Vasturia, and Rajesh Singh recently presented research at FASEB in SnowMass, Colorado. A downloadable PDF of this poster can be found here. […]
UCHL1 The protein encoded by UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a thiol protease belonging to the C12 family of peptidases that hydrolyze peptide bonds at the C-terminal glycine of ubiquitin. So far UCHL1 has been shown to be specifically expressed in neuronal and neuroendocrine tissues within humans. Mutations to this gene are associated with […]
USP14 USP14 is a ubiquitin specific protease that associates with the proteasome. This association with the proteasome has been shown to enhance the enzymatic activity of the proteasome. Recent studies have demonstrated that USP14 expression in certain cancers correlates with metastasis. Using a chemical probe researchers have shown that USP14 can interact with ISG15, a […]
USP8 USP8 is associated with endosomal trafficking, it is not clear that this isopeptidase is involved in the commitment to lysosomal sorting. Additional research has shown that USP8 plays a critical role in the stability of receptor tyrosine kinases. USP8 has been demonstrated to regulate the stability of Nrdp1, a E3 ubiquitin ligase. Among USP8’s […]
E6-AP E6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. It is a HECT domain E3 containing an active site cysteine which accepts a charged ubiquitin from the ubiquitin-E2 thiolester complex. E6-AP has been linked to a neurodevelopmental […]
ITCH ITCH is a HECT E3, which influences immunity, the skin, and plays a role in cancer by targeting various transcription factors and growth factors. Additionally, ITCH functions by ubiquitinylating target substrates for lysosomal degradation, and is associated with K29, K48, and K63 liked ubiquitin. Due to ITCH’s regulator effects on specific transcription and growth […]
NEDD4 Nedd4 is an inner membrane bound HECT E3 that promotes endocytosis of sodium channels marked for degradation at FGFR1 receptors, with K63 linked ubiquitin selectivity. Nedd4 has also been shown to regulate dendritic proliferation and branching during neuronal development. It has also been experimentally demonstrated that Nedd4 is phosphorylated for activation by SRC (Parkin-like). […]
CHIP CHIP is an E3 that coordinates with Ataxin3 to mark misfolded chaperone proteins for UPS degradation. Deficiencies within this pathway are associated with rare disease, such as Spinocerebellar Ataxia, Autosomal Recessive 16 and Gordon Holmes Syndrome.
TAU PROTEINS PDB ID: 5D2V Within healthy neurons, tau proteins are responsible for stabilizing microtubules within the cell. Unfortunately, in instances associated with neurodegenerative disease these proteins are found to aggregate and form bulk tangles within the neuron, leading to a flawed network of neuronal communication and ultimately neuronal degradation. This neurodegeneration is believed to […]
PARKIN PDB ID: 5C1Z Parkin is an E3 ligase, which ubiquitinylates proteins for degradation within neurons, and is primarily associated with mitophagy. By tagging damaged proteins with ubiquitin, the neuron is able to sequester harmful proteins for degradation, perpetuating the lifecycle of the neuron. Research has shown in the absence, or downregulation of Parkin neuronal […]
PARIS (ZNF746) Recently found to have drastic implications in Parkinson’s, researchers have shown PARIS to be a key regulating factor of neuronal death within the substantia nigra (the major site of neuronal degradation within the limbic system). In the absence of Parkin, PARIS is free of ubiquitin and carries out the role of repressing transcription […]
Β-AMYLOID PDB ID: 38KC Amyloid precursor proteins (APP), present in the fatty membrane of neuronal cells, undergo a series of enzymatic cleavages to create smaller proteins known as β-Amyloid. Sometimes, β-Amyloid may be overproduced leading to an accumulation of this protein. The extra β-Amyloid sticks together and creates plaques in neuronal cells. These plaques are […]
PINK1 PDB ID: 50AT PTEN induced putative kinase 1 (PINK1) is important in the role of mitophagy, once it accumulates on the outer membrane of a damaged mitochondria, it summons PARKIN to begin the process of selective autophagy. Together, PINK1 and PARKIN work to control the quality of mitochondrias. If PINK1 is mutated, PARKIN may […]
Α-SYNUCLEIN PDB ID: 1XQ8 α-Synuclein is mainly found in the brain and is present at the presynaptic terminal of neurons. Although its function in a healthy brain is currently unknown, α-Synuclein is believed to take part in maintaining synaptic ventricles as well as regulating the neurotransmitter, dopamine. α-Synuclein is a protein of interest for Parkinson’s […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text] PROTEIN PROFILES MARK TINGEY, DOMINIC VASTURIA, AND KATIE SHEETS Next in its series of educational posts, LifeSensors is proud to discuss the role the proteins play in neurodegenerative diseases. This series of […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text]LifeSensors is a leader in Ubiquitin Proteasome System (UPS) drug discovery technologies and SUMO Platform for Difficult to Express Proteins. We are pleased to inform you that members of our team will be […]
PRESS RELEASE MAY 29, 2018 271 GREAT VALLEY PARKWAY MALVERN, PA 19355 LifeSensors Announces New Distribution Agreement with AmyJet in China LifeSensors Inc, a Biotech and Drug Discovery Company is pleased to announce our new partnership with Chinese distributor AmyJet Scientific. AmyJet Scientific Inc. was established in 2010 in Wuhan, Hubei Province, Tongi, Kowloon. As […]
LIFESENSORS IS PROUD TO SPONSOR THE 2018 FUSION UBIQUITIN CONFERENCE IN NASSAU, BAHAMAS It is with great pride that LifeSensors announces its sponsorship of the 2018 Fusion Conference The Ubiquitin System: Function, Physiology, and its role in Disease. Rather than focusing on structural elements of ubiquitin, this conference will be dedicated to the function of […]
Current Paradigms and Innovative Research Dear Colleagues, Alzheimer’s and Parkinson’s diseases are the silent killers. Despite a massive investment, the failure rate in drug development is 99.6%. The largest hurdle in developing a radical therapy for Alzheimer’s disease (AD) and Parkinson’s Disease (PD) is a lack of a simple diagnostic blood test. Current diagnostics are […]
Dear Colleagues, Deciphering the Ubiquitin Code is the first step in utilizing the Ubiquitin Proteasome System (UPS) to drug the so-called undruggable targets. LifeSensors is proud to present a new technology which will allow for much more precise and accurate targeting of the UPS. The new K48 TUBE HF was developed to show enhanced selectivity […]
UBIQUITIN: HOPE FOR THE FUTURE OF ALZHEIMER’S RESEARCH by: Mark Tingey and Peter Foote Uncle Walt stared at us, not recognizing us or remembering our names. His eyes, which were once bright and filled with curiosity, were now fearful and withdrawn. He appeared to crumple in upon himself, as if the world he no longer […]
WE HAVE DEVELOPED A NEW WEBSITE FOR CUSTOMERS TO FOLLOW OUR INNOVATIONS AND THE FUTURE OF MEDICINE BY EXPLORING THE UBIQUITIN AND SUMO PATHWAY CHECK OUT OUR NEW FEATURES LIFESENSORS HAS DEVELOPED A DRUG DISCOVERY PLATFORM TO TAP INTO THE MOST INNOVATIVE DRUG TARGETS FROM THE UBIQUITIN PROTEASOME SYSTEM (UPS). WE ARE YOUR PARTNERS, FROM […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text] LifeSensors recently presented the work of Rajesh Singh, Cari Sagum, Jianji Chen, Apurva Chaturvedi, Peter Foote, and Mark Bedford at Cold Spring Harbor Laboratories. A PDF of this poster can be downloaded Here. […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text]Lifesensors recently presented the work of Peter Foote, Xialong Lu, Apurva Chaturvedi, and Rajesh Singh at AACR2018. A PDF of this poster can be downloaded here. ABSTRACT Ubiquitylation is a versatile post-translational modification involved […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text] LifeSensors’ Scientists Apurva Chaturvedi, Peter Foote, Dominic Vasturia, and Rajesh Singh recently presented their research at AACR2018. A pdf of this poster can be downloaded here. ABSTRACT Purpose of study: The work presented here […]
