Protein Profiles: UCHL1

By July 10, 2018 October 28th, 2019 No Comments


The protein encoded by UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a thiol protease belonging to the C12 family of peptidases that hydrolyze peptide bonds at the C-terminal glycine of ubiquitin. So far UCHL1 has been shown to be specifically expressed in neuronal and neuroendocrine tissues within humans. Mutations to this gene are associated with Parkinson’s disease.


Leave a Reply