
INTRODUCTION Proteolysis Targeting Chimeras (PROTACs) represent a promising set of drugs that target proteins without an inherent enzymatic activity for proteasomal degradation. Despite all the efforts being invested in PROTAC...
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Autophagy Autophagy is a process by which eukaryotic cells degrade and recycle proteins and organelles using intracellular lysosomes. Malfunctions in autophagy have been shown to induce many diseases including cancer,…
Ubiquitin and Neuroscience Neurodegenerative diseases are often characterized by excessive or dysfunctional proteins and protein aggregates, which induce specific pathological conditions. The ubiquitin proteasome system and autophagy play key roles…
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