You are using an outdated browser. For a faster, safer browsing experience, upgrade for free today.

LifeSensors

Call us: 610.644.8845
10
Jul
Protein Profiles: CHIP

Protein Profiles: CHIP

  • 0
  • 651 Views
CHIPCHIP is an E3 that coordinates with Ataxin3 to mark misfolded chaperone proteins for UPS degradation. Deficiencies within this pathway are associated with rare disease, such as Spinocerebellar Ata...


10
Jul
Protein Profiles: Nedd4

Protein Profiles: Nedd4

  • 0
  • 653 Views
Nedd4Nedd4 is an inner membrane bound HECT E3 that promotes endocytosis of sodium channels marked for degradation at FGFR1 receptors, with K63 linked ubiquitin selectivity. Nedd4 has also been shown...


10
Jul
Protein Profiles: ITCH

Protein Profiles: ITCH

  • 0
  • 534 Views
ITCHITCH is a HECT E3, which influences immunity, the skin, and plays a role in cancer by targeting various transcription factors and growth factors.  Additionally, ITCH functions by ubiquitinyla...


10
Jul
Protein Profiles: E6-AP

Protein Profiles: E6-AP

  • 0
  • 390 Views
E6-APE6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. It is a HECT domain E3 con...


10
Jul
Protein Profiles: USP8

Protein Profiles: USP8

  • 0
  • 387 Views
USP8USP8 is associated with endosomal trafficking, it is not clear that this isopeptidase is involved in the commitment to lysosomal sorting. Additional research has shown that USP8 plays a critica...


10
Jul
Protein Profiles: USP14

Protein Profiles: USP14

  • 0
  • 357 Views
USP14USP14 is a ubiquitin specific protease that associates with the proteasome. This association with the proteasome has been shown to enhance the enzymatic activity of the proteasome. Recent stud...


10
Jul
Protein Profiles: UCHL1

Protein Profiles: UCHL1

  • 0
  • 410 Views
UCHL1The protein encoded by UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a thiol protease belonging to the C12 family of peptidases that hydrolyze peptide bonds at the C-terminal glycine of ubiquiti...


10
Jul
Protein Profiles

Protein Profiles

  • 0
  • 584 Views
Protein ProfilesMark Tingey, Dominic Vasturia, and Katie SheetsNext in its series of educational posts, LifeSensors is proud to discuss the role the proteins play in neurodegenerative diseases.  ...


18
Jun
Protein Profiles: α-Synuclein

Protein Profiles: α-Synuclein

  • 0
  • 675 Views
α-SynucleinPDB ID: 1XQ8α-Synuclein is mainly found in the brain and is present at the presynaptic terminal of neurons. Although its function in a healthy brain is currently unknown, α-Synuclein is b...


06
Jul
Protein Profiles: PINK1

Protein Profiles: PINK1

  • 0
  • 462 Views
PINK1PDB ID: 50ATPTEN induced putative kinase 1 (PINK1) is important in the role of mitophagy, once it accumulates on the outer membrane of a damaged mitochondria, it summons PARKIN to begin the pro...


18
Jun
Protein Profiles: β-Amyloid

Protein Profiles: β-Amyloid

  • 0
  • 744 Views
β-AmyloidPDB ID: 38KCAmyloid precursor proteins (APP), present in the fatty membrane of neuronal cells, undergo a series of enzymatic cleavages to create smaller proteins known as β-Amyloid. Sometim...


19
Jun
Protein Profiles: Paris (ZNF746)

Protein Profiles: Paris (ZNF746)

  • 0
  • 631 Views
Source: https://doi.org/10.1016/j.cell.2011.02.010PARIS (ZNF746)Recently found to have drastic implications in Parkinson’s, researchers have shown PARIS to be a key regulating factor of neuronal...


06
Jul
Protein Profiles: Parkin

Protein Profiles: Parkin

  • 0
  • 356 Views
ParkinPDB ID: 5C1ZParkin is an E3 ligase, which ubiquitinylates proteins for degradation within neurons, and is primarily associated with mitophagy. By tagging damaged proteins with ubiquitin, the n...


18
Jun
Protein Profiles: Tau Proteins

Protein Profiles: Tau Proteins

  • 0
  • 409 Views
Tau ProteinsPDB ID: 5D2VWithin healthy neurons, tau proteins are responsible for stabilizing microtubules within the cell. Unfortunately, in instances associated with neurodegenerative disease these...


23
May
LifeSensors is Proud to Sponsor the 2018 Fusion Ubiquitin Conference in Nassau, Bahamas

LifeSensors is Proud to Sponsor the 2018 Fusion Ubiquitin Conference in Nassau, Bahamas

  • 0
  • 560 Views
LifeSensors is Proud to Sponsor the 2018 Fusion Ubiquitin Conference in Nassau, BahamasIt is with great pride that LifeSensors announces its sponsorship of the 2018 Fusion Conference The Ubiquitin Sys...


22
May
Hope for the Future of Alzheimer's Research

Hope for the Future of Alzheimer's Research

  • 0
  • 427 Views
HOPE FOR THE FUTURE OF ALZHEIMER’S RESEARCHCurrent Paradigms and Innovative ResearchDear Colleagues,Alzheimer's and Parkinson's diseases are the silent killers. Despite a massive investment, the failu...


09
May
Ubiquitin: Hope for the Future of Alzheimer's Research

Ubiquitin: Hope for the Future of Alzheimer's Research

  • 0
  • 4204 Views
Ubiquitin: Hope for the Future of Alzheimer’s Researchby: Mark Tingey and Peter Foote    Uncle Walt stared at us, not recognizing us or remembering our names.  His eyes, which were onc...