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December 14, 2023
Unveiling the Power of TUBEs: Revolutionizing Ubiquitin Research
By: Derrick Padykula Ubiquitination, a ubiquitous cellular process, involves attaching ubiquitin to target proteins, influencing…
![](https://lifesensors.com/wp-content/uploads/2023/03/Degrader-Molecular-Glues-600x403.png)
March 8, 2023
Tragedy to Transformation – Molecular Glue Sparks the Field of Targeted Protein Degradation
By: Isabelle Wentzel Devastating Origins In the late 1950s and early 1960s, pregnant women…
![](https://lifesensors.com/wp-content/uploads/2022/09/E1-E2-E3-Ligase-Cropped-Version-e1681762289587-600x384.jpg)
September 8, 2022
Profiling E3 ligase compounds and the Implications in Drug Discovery
By: Abdul Haseeb, Ph.D. Drugging the Undruggable Tremendous progress in genomics, transcriptomics and proteomics…
![](https://lifesensors.com/wp-content/uploads/2022/09/BBRC-Logo-Wideform-2.jpg)
September 1, 2022
Accelerating PROTAC drug discovery: Establishing a Relationship Between Ubiquitination and Target Protein Degradation
MALVERN, Pa., SEP 1, 2022 – LifeSensors Inc., a Biotech and Drug Discovery Company focused…
![](https://lifesensors.com/wp-content/uploads/2022/01/Email-Blast-Webinar-600x362.png)
February 2, 2022
PROTAC Drug Discovery January 2022 Webinar
PROTAC Drug Discovery Webinar January 2022
![](https://lifesensors.com/wp-content/uploads/2021/08/protacs-600x403.png)
August 12, 2021
The Power of PROTACs
By: Rebekah Varghese, Derrick Padykula, & Jacob Huang All the FDA-approved drugs combined interact with…
![](https://lifesensors.com/wp-content/uploads/2021/07/parkinsons-brain-1-600x345.png)
July 22, 2021
Plunging into the Plight of Parkinson’s Disease
By: Rebekah Varghese and Derrick Padykula Parkinson’s Disease (PD) is the second most common neurodegenerative…
![Schematic of the UPS](https://lifesensors.com/wp-content/uploads/2021/03/UPS-600x403.jpg)
March 1, 2021
Ubiquitin-Proteasome System
The Ubiquitin-Proteasome System: An Overview The Ubiquitin-Proteasome system (UPS) is a highly complex, temporally…
![](https://lifesensors.com/wp-content/uploads/2020/11/iron-brain-alzheiemrs-neuroscieces-600x403.jpg)
November 23, 2020
The Biomarkers of Alzheimer’s Disease
November is a month dedicated to the awareness of Alzheimer’s Disease, an age-related illness of…
![](https://lifesensors.com/wp-content/uploads/2018/06/categories-autophagy-e1572527411636.jpg)
October 31, 2019
Autophagy
Autophagy Autophagy is a process by which eukaryotic cells degrade and recycle proteins and organelles…
![](https://lifesensors.com/wp-content/uploads/2018/07/categories-NeuroImages_DV-e1572527944858.jpg)
October 31, 2019
Ubiquitin and Neuroscience
Ubiquitin and Neuroscience Neurodegenerative diseases are often characterized by excessive or dysfunctional proteins and protein…
![](https://lifesensors.com/wp-content/uploads/2019/07/UMH_L_Dementia@1x-796x408-600x403.jpg)
May 17, 2019
Lewy Body Dementia – Hiding in Plain Sight
Lewy Body Dementia (LBD) is a debilitating neurodegenerative disease that is increasingly becoming a public…
![](https://lifesensors.com/wp-content/uploads/2019/10/alda.jpg)
August 10, 2018
PARKINSON’S DISEASE: BIOMARKERS OF EARLY DISCOVERY
By: Mark Tingey, Katelyn Roberts, and Meredith Paterson Parkinson’s disease is often referred to as…
![](https://lifesensors.com/wp-content/uploads/2019/07/UCHL1.jpg)
July 10, 2018
Protein Profiles: UCHL1
UCHL1 The protein encoded by UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a thiol protease belonging…
![](https://lifesensors.com/wp-content/uploads/2019/07/USP14.jpg)
July 10, 2018
Protein Profiles: USP14
USP14 USP14 is a ubiquitin specific protease that associates with the proteasome. This association with…
![](https://lifesensors.com/wp-content/uploads/2019/07/USP8-600x403.jpg)
July 10, 2018
Protein Profiles: USP8
USP8 USP8 is associated with endosomal trafficking, it is not clear that this isopeptidase is…
![](https://lifesensors.com/wp-content/uploads/2019/07/E6AP.jpg)
July 10, 2018
Protein Profiles: E6-AP
E6-AP E6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the…
![](https://lifesensors.com/wp-content/uploads/2019/07/2NQ3_400x400.png)
July 10, 2018
Protein Profiles: ITCH
ITCH ITCH is a HECT E3, which influences immunity, the skin, and plays a role…
![](https://lifesensors.com/wp-content/uploads/2019/07/Nedd4-796x408-600x403.png)
July 10, 2018
Protein Profiles: Nedd4
NEDD4 Nedd4 is an inner membrane bound HECT E3 that promotes endocytosis of sodium channels…
![](https://lifesensors.com/wp-content/uploads/2019/07/CHIP-796x408-600x403.jpg)
July 10, 2018
Protein Profiles: CHIP
CHIP CHIP is an E3 that coordinates with Ataxin3 to mark misfolded chaperone proteins for…
![](https://lifesensors.com/wp-content/uploads/2019/07/Tau-500x403.jpg)
June 18, 2018
Protein Profiles: Tau Proteins
TAU PROTEINS PDB ID: 5D2V Within healthy neurons, tau proteins are responsible for stabilizing microtubules…
![](https://lifesensors.com/wp-content/uploads/2019/07/Parkin-500x403.jpg)
June 18, 2018
Protein Profiles: Parkin
PARKIN PDB ID: 5C1Z Parkin is an E3 ligase, which ubiquitinylates proteins for degradation within…