December 14, 2023
Unveiling the Power of TUBEs: Revolutionizing Ubiquitin Research
By: Derrick Padykula Ubiquitination, a ubiquitous cellular process, involves attaching ubiquitin to target proteins, influencing…
March 8, 2023
Tragedy to Transformation – Molecular Glue Sparks the Field of Targeted Protein Degradation
By: Isabelle Wentzel Devastating Origins In the late 1950s and early 1960s, pregnant women…
September 8, 2022
Profiling E3 ligase compounds and the Implications in Drug Discovery
By: Abdul Haseeb, Ph.D. Drugging the Undruggable Tremendous progress in genomics, transcriptomics and proteomics…
September 1, 2022
Accelerating PROTAC drug discovery: Establishing a Relationship Between Ubiquitination and Target Protein Degradation
MALVERN, Pa., SEP 1, 2022 – LifeSensors Inc., a Biotech and Drug Discovery Company focused…
February 2, 2022
PROTAC Drug Discovery January 2022 Webinar
PROTAC Drug Discovery Webinar January 2022
August 12, 2021
The Power of PROTACs
By: Rebekah Varghese, Derrick Padykula, & Jacob Huang All the FDA-approved drugs combined interact with…
July 22, 2021
Plunging into the Plight of Parkinson’s Disease
By: Rebekah Varghese and Derrick Padykula Parkinson’s Disease (PD) is the second most common neurodegenerative…
March 1, 2021
Ubiquitin-Proteasome System
The Ubiquitin-Proteasome System: An Overview The Ubiquitin-Proteasome system (UPS) is a highly complex, temporally…
November 23, 2020
The Biomarkers of Alzheimer’s Disease
November is a month dedicated to the awareness of Alzheimer’s Disease, an age-related illness of…
October 31, 2019
Autophagy
Autophagy Autophagy is a process by which eukaryotic cells degrade and recycle proteins and organelles…
October 31, 2019
Ubiquitin and Neuroscience
Ubiquitin and Neuroscience Neurodegenerative diseases are often characterized by excessive or dysfunctional proteins and protein…
May 17, 2019
Lewy Body Dementia – Hiding in Plain Sight
Lewy Body Dementia (LBD) is a debilitating neurodegenerative disease that is increasingly becoming a public…
August 10, 2018
PARKINSON’S DISEASE: BIOMARKERS OF EARLY DISCOVERY
By: Mark Tingey, Katelyn Roberts, and Meredith Paterson Parkinson’s disease is often referred to as…
July 10, 2018
Protein Profiles: UCHL1
UCHL1 The protein encoded by UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a thiol protease belonging…
July 10, 2018
Protein Profiles: USP14
USP14 USP14 is a ubiquitin specific protease that associates with the proteasome. This association with…
July 10, 2018
Protein Profiles: USP8
USP8 USP8 is associated with endosomal trafficking, it is not clear that this isopeptidase is…
July 10, 2018
Protein Profiles: E6-AP
E6-AP E6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the…
July 10, 2018
Protein Profiles: ITCH
ITCH ITCH is a HECT E3, which influences immunity, the skin, and plays a role…
July 10, 2018
Protein Profiles: Nedd4
NEDD4 Nedd4 is an inner membrane bound HECT E3 that promotes endocytosis of sodium channels…
July 10, 2018
Protein Profiles: CHIP
CHIP CHIP is an E3 that coordinates with Ataxin3 to mark misfolded chaperone proteins for…
June 18, 2018
Protein Profiles: Tau Proteins
TAU PROTEINS PDB ID: 5D2V Within healthy neurons, tau proteins are responsible for stabilizing microtubules…
June 18, 2018
Protein Profiles: Parkin
PARKIN PDB ID: 5C1Z Parkin is an E3 ligase, which ubiquitinylates proteins for degradation within…