Specifications
Praja1 (along with Praja2, 53% identity) is a RING-H2 domain E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. Substrates for Praja1 include Dlxin-1 (MAGE-D1, human), which regulates Dlx5 dependent transcriptional function (involved in osteoblast differentiation), and ELF and Smad3, which are involved in the TGF-β signaling pathway implicated in gastrointestinal cancers.
Info
| Species | Human |
| Source | E. coli |
| Tag | His6-SUMO |
| Molecular Weight | 71 kDa |
| Quantity | 25 µg |
| Concentration | Variable |
| Formulation | |
| Storage | -80°C, avoid freeze/thaw cycles |
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