MuRF3 is a RING domain E3 ligase that is involved in the conjugation of ubiquitin to target substrates. MuRF3 has been demonstrated to function with the E2 enzyme UBE2D3 (UbcH5c) in vitro. MuRF3 is also known as TRIM54 (tripartite motif-containing 54) containing a RING-finger/B-box/coiled-coil tripartite fold. MuRF3 has been implicated along with MuRF1 as a regulator of protein degradation in striated muscle. MuRF3 also plays an important role in maintaining cardiac function after myocardial infarction.
|Molecular Weight||52.4 kDa (with tag), 40.3 (without tag)|
|Storage||-80°C, avoid freeze/thaw cycles|