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SI9870: Nutlin-3

LifeSensors SI9870 (Nutlin-3) is a potent molecule that activates p53-regulated genes, exhibiting strong antiproliferative effects in cells with functional p53, aiding cancer research.

$250.00

SKU SI-9870-0005 Categories E1-E2-E3 Inhibitors, Small Molecule Modulators and PROTACs

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Product Advantages

Cis-imidazoline analog that inhibits the interaction between p53 and its negative regulator MDM2 (IC50 = 0.09 μM). It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. Nutlin-3 also inhibits the growth of human tumor xenografts in nude mice by 90% at a dose of 200 mg/kg.

Info

Purity	>98% (TLC), NMR (conforms)
Quantity	5 mg
Molecular Weight	581.5 Da
Physical State	White crystalline solid
Solubility	DMSO (50mg/ml)
CAS No.	548472-68-0
Storage	4°C, (-20°C Long term). The product can be shipped at room temperature.

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