PR-619 is a non-selective, reversible inhibitor of deubiquitinases/deubiquitylases (DUBs) and ubiquitin-like isopeptidases. PR-619 inhibits many deubiquitinating enzymes in the 5-20 µM range. Additionally, PR-619 is cell-permeable and treatment of cells results in the accumulation of both ubiquitin and sumo-conjugated proteins.
|Purity||≥ 95% (RP-HPLC)|
|Quantity||5 mg; 25 mg|
|Molecular Weight||223.28 Da; measured M+H+ = 224.11|
|Physical State||Dry powder|
|Solubility||> 5 mg/mL in DMSO|
|Storage||4 °C, with long term storage down to -20°C. Product can be shipped at room temperature.|
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