Specifications
Containing the active ingredient of MLN4924 which acts as a substrate-assisted inhibitor of the NEDD8-activating enzyme (NAE). NAE activates NEDD8 (Neural precursor cell expressed, developmentally down-regulated 8) for conjugation to a variety of ubiquitin E3 ligases. NEDD8-MLN4924 adducts bind and inhibit NAE, which may result in the inhibition of tumor cell proliferation and survival. This cell-permeable compound selectively inhibits NAE activity and results in inhibition of the NEDD8 pathway.
Info
| Purity | >98% (TLC), NMR (conforms) |
| Quantity | 1 mg |
| Molecular Weight | 443.2 Da |
| Physical State | White powder |
| Solubility | DMSO (10 mg/ml) |
| CAS No. | 905579-51-3 |
| Storage | 4°C, (-20°C Long term). The product can be shipped at room temperature. |
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