SI9830: MLN-4924


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Containing the active ingredient of MLN4924 which acts as a substrate-assisted inhibitor of the NEDD8-activating enzyme (NAE). NAE activates NEDD8 (Neural precursor cell expressed, developmentally down-regulated 8) for conjugation to a variety of ubiquitin E3 ligases. NEDD8-MLN4924 adducts bind and inhibit NAE, which may result in the inhibition of tumor cell proliferation and survival. This cell-permeable compound selectively inhibits NAE activity and results in inhibition of the NEDD8 pathway.


Purity >98% (TLC), NMR (conforms)
Quantity 1 mg
Molecular Weight 443.2 Da
Physical State White powder
Solubility DMSO (10 mg/ml)
CAS No. 905579-51-3
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.

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  • Inhibition of NEDD8-dependent pathways.
  • Benefits: cell-permeable