SI9840: TAME HCl


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Inhibits the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) by inhibiting binding and activation by the APC activators Cdc20 and Cdh1. TAME inhibits cyclin proteolysis in Xenopus extracts (IC50 = 12 µM) and inhibits Cdc20 association with APC at 200 µM. It stabilizes cyclin B1 by prematurely terminating ubiquitination. Substrate for trypsin, thrombin, plasmin, and other proteases.


Purity >98% (TLC); NMR (Conforms)
Quantity 100 mg
Molecular Weight 378.9 Da
Physical State White Powder
Solubility May be dissolved in DMSO (35 mg/mL); or water (35 mg/mL)
CAS No. 1784-03-8
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.

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  • Inhibition of the APC/C ubiquitin ligase.