Specifications
Inhibits the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) by inhibiting binding and activation by the APC activators Cdc20 and Cdh1. TAME inhibits cyclin proteolysis in Xenopus extracts (IC50 = 12 µM) and inhibits Cdc20 association with APC at 200 µM. It stabilizes cyclin B1 by prematurely terminating ubiquitination. Substrate for trypsin, thrombin, plasmin, and other proteases.
Info
| Purity | >98% (TLC); NMR (Conforms) |
| Quantity | 100 mg |
| Molecular Weight | 378.9 Da |
| Physical State | White Powder |
| Solubility | May be dissolved in DMSO (35 mg/mL); or water (35 mg/mL) |
| CAS No. | 1784-03-8 |
| Storage | 4°C, (-20°C Long term). The product can be shipped at room temperature. |
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