SI9850: NSC-66811

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Specifications

A cell-permeable, non-peptide inhibitor of MDM2-p53 interactions (Ki=120nM). Treatment of cancer cells activates p53 and accumulation of p21, p53, and MDM2. The structure mimics three p53 residues involved in binding to MDM2.

Info

Purity >97% (TLC, HPLC), NMR (conforms)
Quantity 10 mg
Molecular Weight 340.4 Da
Physical State White solid
Solubility DMSO (25mg/ml)
CAS No. 6964-62-1
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.

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Applications

  • Cell-based studies of MDM2 and p53 function
  • Comparative studies of new MDM2 or p53 inhibitors

Benefits

  • Cell-permeable
  • Non-peptide inhibitor of MDM2-p53 interactions
  • nM potency

 

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