SI9855: PTC-209


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Treatment of cells with PTC-209 leads to the selective reduction in the levels of BMI-1 protein (Kreso, van Galen et al. 2014). BMI-1 is a component of the polycomb PRC complex and interacts directly with the E3 ligase RING1A and/or RING2. The PRC complex mediates monoubiquitylation of histone H2A on Lys-119 and is involved in chromatin remodeling and repression of gene expression.


Purity 99%; NMR consistent with structure
Quantity 5 mg
Molecular Weight 576.1 Da
Physical State Powder
Solubility 173mM in DMSO
CAS No. 1217022-63-3
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.

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  • Studying the function of BMI-1