A potent inhibitor of histone H2A ubiquitylation. Inhibits RNF2 and Ring1A, both of which are found in polycomb repressive complex 1 (PRC1). Does not inhibit RNF8 or RNF168. Inhibits accumulation of ubiquitin around DNA double-strand breaks (DSBs) as well as the repair of DSBs.
|Purity||> 98% (TLC); NMR (conforms)|
|Molecular Weight||235.2 Da|
|Physical State||Dry yellow powder|
|Storage||4°C, (-20°C Long term). Store solutions at -20°C. The product can be shipped at room temperature.|