Thalidomide binds to the E3 ubiquitin ligase complex formed between cereblon (CRBN), damaged DNA binding protein 1 (DDB1), and Cul4A inhibiting ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Thalidomide initiates its teratogenic effects by binding to CRBN and inhibiting the associated ubiquitin E3 ligase activity. Cell permeable.
|Purity||>98% (TLC); NMR (Conforms)|
|Quantity||100 mg, 200 mg|
|Molecular Weight||258.2 Da|
|Physical State||White powder|
|Solubility||DMSO (5 mg/ml)|
|Storage||4°C, (-20°C Long term). Store solutions at -20°C for up to three months. The product can be shipped at room temperature.|