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SI9820: Thalidomide, CRBN Ligase Modulator

LifeSensors SI9820 (Thalidomide) is a CRBN ligase modulator that inhibits E3 ubiquitin ligases, used in research to study protein degradation and ubiquitin pathways. High purity >98%.

$122.00 – $213.00

SKU SI-9820 Categories E1-E2-E3 Inhibitors, Small Molecule Modulators and PROTACs

Weight

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Product Advantages

Inhibition of E3 ubiquitin ligases
Cell biology
Drug discovery
Benefits: cell-permeable

Thalidomide binds to the E3 ubiquitin ligase complex formed between cereblon (CRBN), damaged DNA binding protein 1 (DDB1), and Cul4A inhibiting ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Thalidomide initiates its teratogenic effects by binding to CRBN and inhibiting the associated ubiquitin E3 ligase activity. Cell permeable.

Caution: Teratogenic

Info

Purity	>98% (TLC); NMR (Conforms)
Quantity	100 mg, 200 mg
Molecular Weight	258.2 Da
Physical State	White powder
Solubility	DMSO (5 mg/ml)
CAS No.
Storage	4°C, (-20°C Long term). Store solutions at -20°C for up to three months. The product can be shipped at room temperature.

Document 1

Document 1

Inhibition of E3 ubiquitin ligases
Cell biology
Drug discovery
Benefits: cell-permeable

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PROTAC IS A REGISTERED TRADEMARK OF ARVINAS OPERATIONS, INC., AND IS USED UNDER LICENSE.

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