UPS Inhibitor

SI9820: Thalidomide, CRBN Ligase Modulator

$95.00$165.00

Clear

Specifications

Thalidomide binds to the E3 ubiquitin ligase complex formed between cereblon (CRBN), damaged DNA binding protein 1 (DDB1), and Cul4A inhibiting ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Thalidomide initiates its teratogenic effects by binding to CRBN and inhibiting the associated ubiquitin E3 ligase activity. Cell permeable.

Caution: Teratogenic

 

Info

Purity >98% (TLC); NMR (Conforms)
Quantity 100 mg, 200 mg
Molecular Weight 258.2 Da
Physical State White powder
Solubility DMSO (5 mg/ml)
CAS No.
Storage 4°C, (-20°C Long term). Store solutions at -20°C for up to three months. The product can be shipped at room temperature.

Additional information

Weight

100 mg, 200 mg

Reviews

There are no reviews yet.

Be the first to review “SI9820: Thalidomide, CRBN Ligase Modulator”
  • Inhibition of E3 ubiquitin ligases
  • Cell biology
  • Drug discovery
  • Benefits: cell-permeable