Specifications
Thalidomide binds to the E3 ubiquitin ligase complex formed between cereblon (CRBN), damaged DNA binding protein 1 (DDB1), and Cul4A inhibiting ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Thalidomide initiates its teratogenic effects by binding to CRBN and inhibiting the associated ubiquitin E3 ligase activity. Cell permeable.
Caution: Teratogenic
Info
Purity | >98% (TLC); NMR (Conforms) |
Quantity | 100 mg, 200 mg |
Molecular Weight | 258.2 Da |
Physical State | White powder |
Solubility | DMSO (5 mg/ml) |
CAS No. | |
Storage | 4°C, (-20°C Long term). Store solutions at -20°C for up to three months. The product can be shipped at room temperature. |
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