Specifications
Cis-imidazoline analog that inhibits the interaction between p53 and its negative regulator MDM2 (IC50 = 0.09 μM). It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. Nutlin-3 also inhibits the growth of human tumor xenografts in nude mice by 90% at a dose of 200 mg/kg.
Info
| Purity | >98% (TLC), NMR (conforms) |
| Quantity | 5 mg |
| Molecular Weight | 581.5 Da |
| Physical State | White crystalline solid |
| Solubility | DMSO (50mg/ml) |
| CAS No. | 548472-68-0 |
| Storage | 4°C, (-20°C Long term). The product can be shipped at room temperature. |
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