AC2007: Brefeldin A

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Specifications

Brefeldin A is a cell permeable fermentation product from Penicillium brefeldianum. It is a lactone antibiotic and ATPase inhibitor for protein transport with an IC50 of 0.2 μM in HCT 116 cells. Brefeldin A has been widely used as specific inhibitor of protein translocation from endoplasmic reticulum to Golgi. It blocks secretion and prevents the assembly of non-clathrin-coated buds on Golgi cisternae. Brefeldin A also inhibits guanine nucleotide-exchange proteins BIG1 and BIG2, activators of ADP-ribosylation factors. It induces apoptosis independently of p53 and  activates sphingomyelin metabolism.

Info

Purity >99.0% by HPLC
Quantity 5 mg, 25 mg, 50 mg
Molecular Weight 280.4 g/mol
Physical State Lyophilized powder
Solubility 100 mg/mL in DMSO; or 25 mg/ml in warm ethanol
CAS No. 20350-15-6
Storage -20°C, avoid freeze/thaw cycles

Additional information

Weight

5 mg, 25 mg, 50 mg

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