AC2007: Brefeldin A

Lifesensors AC2007 (Brefeldin A) is a cell-permeable lactone antibiotic that inhibits ATPase, disrupting protein transport and modulating autophagy in cellular studies

$108.00 – $609.00

SKU AC-2007 Categories Autophagy Inducers, Autophagy Modulators, Small Molecule Modulators and PROTACs

Product Advantages

Brefeldin A is a cell permeable fermentation product from Penicillium brefeldianum. It is a lactone antibiotic and ATPase inhibitor for protein transport with an IC₅₀ of 0.2 μM in HCT 116 cells. Brefeldin A has been widely used as specific inhibitor of protein translocation from endoplasmic reticulum to Golgi. It blocks secretion and prevents the assembly of non-clathrin-coated buds on Golgi cisternae. Brefeldin A also inhibits guanine nucleotide-exchange proteins BIG1 and BIG2, activators of ADP-ribosylation factors. It induces apoptosis independently of p53 and activates sphingomyelin metabolism.

Info

Purity	>99.0% by HPLC
Quantity	5 mg, 25 mg, 50 mg
Molecular Weight	280.4 g/mol
Physical State	Lyophilized powder
Solubility	100 mg/mL in DMSO; or 25 mg/ml in warm ethanol
CAS No.	20350-15-6
Storage	-20°C, avoid freeze/thaw cycles