Specifications
PYR-41 is a cell permeable, irreversible inhibitor of ubiquitin activating enzyme E1 with little or no activity against E2s or E3s (IC50 < 10 μM). It blocks degradation of p53 and inhibits NF-κB-dependent pathways. PYR-41 also increases SUMOylation of protein.
Info
| Purity | > 98% (TLC); NMR (Conforms) |
| Quantity | 10 mg, 25 mg, 50 mg |
| Molecular Weight | 371.3 Da |
| Physical State | Brown powder |
| Solubility | DMSO (25mg/mL) |
| CAS No. | 418805-02-4 |
| Storage | 4°C, (-20°C Long term). Store solutions at -20°C for up to one week. The product can be shipped at room temperature. |
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