PYR-41 is a cell permeable, irreversible inhibitor of ubiquitin activating enzyme E1 with little or no activity against E2s or E3s (IC50 < 10 μM). It blocks degradation of p53 and inhibits NF-κB-dependent pathways. PYR-41 also increases SUMOylation of protein.
|Purity||> 98% (TLC); NMR (Conforms)|
|Quantity||10 mg, 25 mg, 50 mg|
|Molecular Weight||371.3 Da|
|Physical State||Brown powder|
|Storage||4°C, (-20°C Long term). Store solutions at -20°C for up to one week. The product can be shipped at room temperature.|