Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

SI9810: PYR-41 conjugating enzyme inhibitor

LifeSensors SI9810 (PYR-41) is a cell-permeable, irreversible inhibitor of ubiquitin-activating enzyme E1, with IC50 < 10 µM, used in research on protein ubiquitination and degradation.

Price range: $225.00 through $693.00

PYR-41 is a cell permeable, irreversible inhibitor of ubiquitin activating enzyme E1 with little or no activity against E2s or E3s (IC50 < 10 μM). It blocks degradation of p53 and inhibits NF-κB-dependent pathways. PYR-41 also increases SUMOylation of protein.

Info

Purity > 98% (TLC); NMR (Conforms)
Quantity 10 mg, 25 mg, 50 mg
Molecular Weight 371.3 Da
Physical State Brown powder
Solubility DMSO (25mg/mL)
CAS No. 418805-02-4
Storage 4°C, (-20°C Long term). Store solutions at -20°C for up to one week. The product can be shipped at room temperature.
  • USP10/USP13 inhibition
  • Inhibition of autophagy
  • Benefits: cell-permeable

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

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