SI9810: PYR-41 conjugating enzyme inhibitor




PYR-41 is a cell permeable, irreversible inhibitor of ubiquitin activating enzyme E1 with little or no activity against E2s or E3s (IC50 < 10 μM). It blocks degradation of p53 and inhibits NF-κB-dependent pathways. PYR-41 also increases SUMOylation of protein.


Purity > 98% (TLC); NMR (Conforms)
Quantity 10 mg, 25 mg, 50 mg
Molecular Weight 371.3 Da
Physical State Brown powder
Solubility DMSO (25mg/mL)
CAS No. 418805-02-4
Storage 4°C, (-20°C Long term). Store solutions at -20°C for up to one week. The product can be shipped at room temperature.

Additional information


10 mg, 25 mg, 50 mg


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  • USP10/USP13 inhibition
  • Inhibition of autophagy
  • Benefits: cell-permeable