3-Methyladenine inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K). It protects 1321N1 astrocytoma cells against pyocyanin and hydroxyphenazine-induced toxicity. Inhibition of autophagy by 3-MA leads to enhanced apoptosis induced by a variety of agents including celastrol, cisplatin and sorafenib in several different cell lines.
|Purity||>98% by TLC|
|Quantity||25 mg, 50 mg, 100 mg|
|Molecular Weight||149.2 g/mol|
|Physical State||Lyophilized white powder|
|Solubility||3 mg/ml in DMSO; 10 mg/mL in warm DMF; 5 mg/mL in water|
|Storage||-20°C, avoid freeze/thaw cycles|