Specifications
3-Methyladenine inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K). It protects 1321N1 astrocytoma cells against pyocyanin and hydroxyphenazine-induced toxicity. Inhibition of autophagy by 3-MA leads to enhanced apoptosis induced by a variety of agents including celastrol, cisplatin and sorafenib in several different cell lines.
Info
| Purity | >98% by TLC |
| Quantity | 25 mg, 50 mg, 100 mg |
| Molecular Weight | 149.2 g/mol |
| Physical State | Lyophilized white powder |
| Solubility | 3 mg/ml in DMSO; 10 mg/mL in warm DMF; 5 mg/mL in water |
| CAS No. | 5142-23-4 |
| Storage | -20°C, avoid freeze/thaw cycles |
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