IU1 is a cell-permeable, reversible, and selective inhibitor of the proteasome-associated DUB USP14 (IC50 < 4 µM). IU1 enhances proteasome activity and substrate proteolysis. IU1 promotes cell survival under stress conditions and selectively stimulates ubiquitin-dependent protein degradation in vitro.
|Purity||> 98% (TLC), NMR (Conforms)|
|Molecular Weight||300.4 Da|
|Physical State||Beige powder|
|Solubility||DMSO (30 mg/mL)|
|Storage||4°C, (-20°C Long term). The product can be shipped at room temperature.|