LY-294002 is a cell permeable highly selective inhibitor of phosphatidylinositol 3-kinase (IC50 = 0.31, 0.73, 1.06 and 6.60 µM for PI 3-Kβ, PI 3-Kα, PI 3-Kδ and PI 3-Kγ respectively). It inhibits autophagy in rat hepatocytes (IC50 = 10 µM). LY-294002 is an extremely useful tool for determining the role of PI 3-K in cellular signaling. It is more stable in solution than Wortmannin, and also blocks autophagosome formation.
|Purity||>98% by TLC|
|Quantity||5 mg, 25 mg|
|Molecular Weight||307.4 g/mol|
|Physical State||Lyophilized white powder|
|Solubility||20mg/mL in warm DMSO; 8 mg/mL in warm ethanol|
|Storage||-20°C, avoid freeze/thaw cycles|