AC1008: Xanthohumol




Xanthohumol binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II). It also impairs prostate cancer cell growth and proliferation. Xanthohumol suppresses the growth of pancreatic cancer cells via down-regulation of Notch1 signaling. Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects.


Purity >98% by TLC
Quantity 5 mg, 25 mg
Molecular Weight 354.4 g/mol
Physical State Lyophilized yellow powder
Solubility 35 mg/mL in DMSO or ethanol
CAS No. 6754-58-1
Storage -20°C, avoid freeze/thaw cycles

Additional information


5 mg, 25 mg


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Impairs autophagosome maturation