Xanthohumol binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II). It also impairs prostate cancer cell growth and proliferation. Xanthohumol suppresses the growth of pancreatic cancer cells via down-regulation of Notch1 signaling. Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects.
|Purity||>98% by TLC|
|Quantity||5 mg, 25 mg|
|Molecular Weight||354.4 g/mol|
|Physical State||Lyophilized yellow powder|
|Solubility||35 mg/mL in DMSO or ethanol|
|Storage||-20°C, avoid freeze/thaw cycles|