UB302: CARP2

$456.75

In stock

SKU: UB-0302-0025 Category: Tag:

Specifications

CARP2 (caspase 8/10 associated RING protein 2) is a RING-domain E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates, along with E1 and E2 enzymes. CARPs (CARP1 and CARP2, 77% identity) also belong to the IAP family (inhibitors of apoptosis proteins) inhibiting activation of DED (death effector domain) containing caspase proteins (8 and 10). In addition to targeting caspases 8 and 10, CARPs have been shown to target phosphorylated p53 for degradation in an Hdm2 independent manner. Furthermore, CARP2 has been shown to be a negative regulator of TNF induced NF-κB activation by targeting RIP for degradation.

Info

Species Human
Source E. coli
Tag His6-SUMO
Molecular Weight 41 kDa
Quantity 25 µg
Concentration Variable
Formulation
Storage -80°C, avoid freeze/thaw cycles

Additional information

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