UB304: E6AP


In stock


E6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. It is a HECT domain E3 containing an active site cysteine that accepts a charged ubiquitin from the ubiquitin-E2 thioester complex. E6-AP has been linked to the neurodevelopmental disorder, Angelman syndrome. Additionally, the oncoprotein E6 of human papillomaviruses (HPV) utilizes E6-AP to target numerous cellular proteins for degradation including the tumor suppressor protein p53.


Species Human
Source E. coli
Tag None
Molecular Weight 101 kDa
Quantity 25 µg
Concentration Variable
Formulation 20 mM Hepes pH7.5, 150mM NaCl, 10% Glycerol
Storage -80°C, avoid freeze/thaw cycles

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  • Typical enzyme concentration of 100 nM – 5 µM is used for in vitro conjugation, depending on conditions.