UB215H: UBE2H, His6




UBE2H is an E2 conjugation enzyme that is involved in the ubiquitylation of target substrates, along with E1 and E3 enzymes. UBE2H can mediate the transfer of ubiquitin from ubiquitin-activating enzyme E1 to a substrate protein or E3 ligase. UBE2H is a ubiquitin conjugating enzyme known to act on histones and cytoskeletal proteins, both involved in the degenerative pathway of the motor neuron. It has also been shown to ubiquitylate Histone H2A in vitro.


Species Human
Source E. coli
Tag His6
Molecular Weight 21,649.6 Da
Quantity 0.8 nmol, 3.0 nmol
Concentration 40 µM
Formulation 50 mM Tris pH 7.5, 150 mM NaCl, 10 mM DTT, 10% glycerol
Storage -80°C, avoid freeze/thaw cycles

Additional information


0.8 nmol, 3 nmol


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  • Identify cognate E2/E3 pairs
  • Characterize upregulation/downregulation of E2 enzymes
  • Build poly-ubiquitin chains
  • Characterize ubiquitin chain specificity of E2 enzymes
  • Analyze expression of E2 enzymes


  • Untagged (native) E2 conjugation enzyme