Inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding. In cancer cells, the compound induces p27 accumulation and promotes cell type-specific blocks in G1 or G2/M phases.
|Purity||98% by TLC; NMR (conforms)|
|Molecular Weight||465.34 Da|
|Physical State||Lyophilized solid|
|Solubility||DMSO (58mg/ml); Ethanol (8mg/ml); Water (<1mg/ml)|
|Storage||Store desiccated as supplied at 4ºC; Product can be shipped at room temperature.|