Specifications
Inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding. In cancer cells, the compound induces p27 accumulation and promotes cell type-specific blocks in G1 or G2/M phases.
Info
| Purity | 98% by TLC; NMR (conforms) |
| Quantity | 5 mg |
| Molecular Weight | 465.34 Da |
| Physical State | Lyophilized solid |
| Solubility | DMSO (58mg/ml); Ethanol (8mg/ml); Water (<1mg/ml) |
| CAS No. | 432001-69-9 |
| Storage | Store desiccated as supplied at 4ºC; Product can be shipped at room temperature. |
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