SI9880: SMER3

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Specifications

Small Molecule Enhancer of Rapamycin 3 (SMER3) is a specific inhibitor of the ubiquitin E3 ligase SCFMET30. SMER3 binds directly to the F-box subunit Met30 and blocks binding to the SCF core complex. This inhibitor is cell permeable. Significant inhibition is typically seen at 30-100 μM.

Info

Purity >98% (TLC), NMR (conforms)
Quantity 10 mg, 25 mg, 50 mg
Molecular Weight 224.2 Da
Physical State Yellow powder
Solubility DMSO (20mg/ml), requires heating
CAS No. 67200-34-4
Storage 4°C, (-20°C Long term). Store solutions at -20 °C for up to 2 months. The product can be shipped at room temperature.

Additional information

Size

10 mg, 25 mg, 50 mg

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Applications

  • Cell-based or in vitro inhibition of SCFMET30

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