One of the most potent and selective proteasome inhibitors, Epoxomycin inhibits all three activities of the proteasome. Epoxomicin (100 nM) results in a 30-fold increase in the levels of p53 protein, a known target of the proteasome, in HUVECs. Epoxomicin (10 μM) results in the accumulation of ubiquitinated proteins in HeLa cells. Epoxomicin (10 μM) inhibits IκBα degradation by 10-fold in HeLa cells.
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|Purity||>99.0% by HPLC|
|Molecular Weight||554.72 Da|
|Physical State||Lyophilized powder|
|Solubility||DMSO (10 mg/mL)|
|Storage||4°C, (-20°C Long term). The product can be shipped at room temperature.|