Specifications
E64D is a cell permeable derivative of E64-C, an inhibitor of calpain and other cysteine proteases, such as papain, cathepsin B and cathepsin L. Addition of E64D to cell cultures should be done in serum-free media, as esterases in serum will cleave the ethyl ester and reduce cell permeability. Typical working concentration of E64D is 0.5-10 μg/ml. E64D inhibits degradation of autophagic cargo inside autolysosomes.
Info
| Purity | 98.0% by HPLC |
| Quantity | 1 mg, 5 mg |
| Molecular Weight | 342.4 g/mol |
| Physical State | Lyophilized white to off-white powder |
| Solubility | 20 mg/mL in DMSO, 10mg/mL in ethanol |
| CAS No. | 88321-09-9 |
| Storage | -20°C, avoid freeze/thaw cycles |
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