AC1004: E64D




E64D is a cell permeable derivative of E64-C, an inhibitor of calpain and other cysteine proteases, such as papain, cathepsin B and cathepsin L. Addition of E64D to cell cultures should be done in serum-free media, as esterases in serum will cleave the ethyl ester and reduce cell permeability. Typical working concentration of E64D is 0.5-10 μg/ml. E64D inhibits degradation of autophagic cargo inside autolysosomes.


Purity 98.0% by HPLC
Quantity 1 mg, 5 mg
Molecular Weight 342.4 g/mol
Physical State Lyophilized white to off-white powder
Solubility 20 mg/mL in DMSO, 10mg/mL in ethanol
CAS No. 88321-09-9
Storage -20°C, avoid freeze/thaw cycles

Additional information


1 mg, 5 mg


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Inhibits proteolysis of autophagic cargo