Specifications
p97 (aka VCP, Cdc48) is intimately involved in the ERAD process through the retrotranslocation of misfolded proteins targeted for degradation by the proteasome. It is a homohexamer of AAA+ ATPase subunits and ATP hydrolysis is required for protein extraction from the ER. NMS-873 is an allosteric inhibitor of ATPase activity, binding to the D1 and D2 domains of adjacent subunits (Magnaghi, D’Alessio et al. 2013). NMS-873 is reported to have an IC50 for p97 of 20-30nM.
Info
| Purity | 99% (TLC), NMR(conforms) |
| Quantity | 5 mg |
| Molecular Weight | 520.67 Da |
| Physical State | Powder |
| Solubility | 192mM in DMSO |
| CAS No. | 1418013-75-8 |
| Storage | 4°C, (-20°C Long term). The product can be shipped at room temperature. |
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