SI9710: MG-132, proteasome inhibitor

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Specifications

MG-132 is a potent, cell-permeable inhibitor of the proteasome (IC50=0.1 µM) and calpain (IC50=1.2 μM). MG-132 inhibits TNF-α-induced NF-κB activation and IκBα degradation (IC50=3 µM). MG-132 reduces the degradation of ubiquitin-conjugated proteins in different cell types and promotes apoptosis via activation of c-Jun N-terminal kinase (JNK1).

Info

Purity > 98% (HPLC)
Quantity 10 mg, 25 mg
Molecular Weight 475.6 Da
Physical State White powder
Solubility DMSO (45 mg/mL) or Ethanol (45 mg/mL)
CAS No. 133407-82-6
Storage 4°C, (-20°C Long term). Store solutions at -20°C for
up to one week.  The product can be shipped at room temperature.

Additional information

Weight

10 mg, 25 mg

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  • Inhibition of 20S proteasome chymotrypsin-like activity.