MG-132 is a potent, cell-permeable inhibitor of the proteasome (IC50=0.1 µM) and calpain (IC50=1.2 μM). MG-132 inhibits TNF-α-induced NF-κB activation and IκBα degradation (IC50=3 µM). MG-132 reduces the degradation of ubiquitin-conjugated proteins in different cell types and promotes apoptosis via activation of c-Jun N-terminal kinase (JNK1).
|Purity||> 98% (HPLC)|
|Quantity||10 mg, 25 mg|
|Molecular Weight||475.6 Da|
|Physical State||White powder|
|Solubility||DMSO (45 mg/mL) or Ethanol (45 mg/mL)|
|Storage||4°C, (-20°C Long term). Store solutions at -20°C for
up to one week. The product can be shipped at room temperature.