Specifications
MG-132 is a potent, cell-permeable inhibitor of the proteasome (IC50=0.1 µM) and calpain (IC50=1.2 μM). MG-132 inhibits TNF-α-induced NF-κB activation and IκBα degradation (IC50=3 µM). MG-132 reduces the degradation of ubiquitin-conjugated proteins in different cell types and promotes apoptosis via activation of c-Jun N-terminal kinase (JNK1).
Info
| Purity | > 98% (HPLC) |
| Quantity | 10 mg, 25 mg |
| Molecular Weight | 475.6 Da |
| Physical State | White powder |
| Solubility | DMSO (45 mg/mL) or Ethanol (45 mg/mL) |
| CAS No. | 133407-82-6 |
| Storage | 4°C, (-20°C Long term). Store solutions at -20°C for up to one week. The product can be shipped at room temperature. |
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