SI9752: NMS-873


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p97 (aka VCP, Cdc48) is intimately involved in the ERAD process through the retrotranslocation of misfolded proteins targeted for degradation by the proteasome. It is a homohexamer of AAA+ ATPase subunits and ATP hydrolysis is required for protein extraction from the ER. NMS-873 is an allosteric inhibitor of ATPase activity, binding to the D1 and D2 domains of adjacent subunits (Magnaghi, D’Alessio et al. 2013). NMS-873 is reported to have an IC50 for p97 of 20-30nM.


Purity 99% (TLC), NMR(conforms)
Quantity 5 mg
Molecular Weight 520.67 Da
Physical State Powder
Solubility 192mM in DMSO
CAS No. 1418013-75-8
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.

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  • Inhibition of ERAD
  • Induction of apoptosis in cancer cells