PS-341 (Pyz-Phe-boroLeu) is the active ingredient in Bortezomib (Velcade). PS-341 is a reversible, cell-permeable, potent, and selective proteasome inhibitor (Ki = 0.6 nM). It binds the catalytic site of the 26S proteasome with high affinity and specificity. Inhibits proliferation of a number of tumor cell lines (IC50 = 7 nM). Inhibits TNF synthesis and FGF-induced angiogenesis.
|Purity||>98% (HPLC), NMR (conforms)|
|Quantity||5 mg, 25 mg|
|Molecular Weight||384.24 Da|
|Physical State||White powder|
|Solubility||DMSO (76 mg/mL)|
|Storage||4°C, (-20°C Long term). The product can be shipped at room temperature.|