P22077 is a cell-permeable inhibitor of the ubiquitin-specific protease USP7 (IC50 = 8.6 μM), and the closely related deubiquitinase (DUB) USP47. P22077 showed weak or no inhibition (EC50 > 50 μM) towards a panel of 14 isopeptidases and other proteases. Treatment of cells with P22077 (20-40 μM) causes an accumulation of K48-linked ubiquitinated species, and downregulation of the USP7 targets HDM2 and claspin.
|Purity||>98% (HPLC), NMR (conforms)|
|Quantity||10 mg, 50 mg|
|Molecular Weight||315.3 Da|
|Physical State||Light powder|
|Storage||4°C, (-20°C Long term). Store solutions
at -20°C for up to one month. The product can be shipped at room temperature.