Specifications
P22077 is a cell-permeable inhibitor of the ubiquitin-specific protease USP7 (IC50 = 8.6 μM), and the closely related deubiquitinase (DUB) USP47. P22077 showed weak or no inhibition (EC50 > 50 μM) towards a panel of 14 isopeptidases and other proteases. Treatment of cells with P22077 (20-40 μM) causes an accumulation of K48-linked ubiquitinated species, and downregulation of the USP7 targets HDM2 and claspin.
Info
| Purity | >98% (HPLC), NMR (conforms) |
| Quantity | 10 mg, 50 mg |
| Molecular Weight | 315.3 Da |
| Physical State | Light powder |
| Solubility | DMSO |
| CAS No. | 1247819-59-5 |
| Storage | 4°C, (-20°C Long term). Store solutions at -20°C for up to one month. The product can be shipped at room temperature. |
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