SI9699: P22077 Inhibitor




P22077 is a cell-permeable inhibitor of the ubiquitin-specific protease USP7 (IC50 = 8.6 μM), and the closely related deubiquitinase (DUB) USP47. P22077 showed weak or no inhibition (EC50 > 50 μM) towards a panel of 14 isopeptidases and other proteases. Treatment of cells with P22077 (20-40 μM) causes an accumulation of K48-linked ubiquitinated species, and downregulation of the USP7 targets HDM2 and claspin.


Purity >98% (HPLC), NMR (conforms)
Quantity 10 mg, 50 mg
Molecular Weight 315.3 Da
Physical State Light powder
Solubility DMSO
CAS No. 1247819-59-5
Storage 4°C, (-20°C Long term). Store solutions
at -20°C for up to one month.  The product can be shipped at room temperature.

Additional information


10 mg, 50 mg


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  • Inhibition of USP7 and USP47 activity.