Specifications
LDN-57444 is a cell permeable ubiquitin C-terminal hydrolase (UCH-L1) inhibitor (Ki=0.4 µM) with approximately 28-fold greater selectivity over UCH-L3. Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis and causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. LDN-57444 is a useful tool to study UCH-L1 in different pathological conditions such as cancer and neurodegeneration.
Info
| Purity | > 98% (TLC); NMR (Conforms) |
| Quantity | 10 mg, 50 mg |
| Molecular Weight | 397.6 Da |
| Physical State | Yellow powder |
| Solubility | DMSO (20 mg/mL) |
| CAS No. | 668467-91-2 |
| Storage | 4°C, (-20°C Long term). Store solutions at -20°C for up to one week. Protect from light. The product can be shipped at room temperature. |
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