LDN-57444 is a cell permeable ubiquitin C-terminal hydrolase (UCH-L1) inhibitor (Ki=0.4 µM) with approximately 28-fold greater selectivity over UCH-L3. Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis and causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. LDN-57444 is a useful tool to study UCH-L1 in different pathological conditions such as cancer and neurodegeneration.
|Purity||> 98% (TLC); NMR (Conforms)|
|Quantity||10 mg, 50 mg|
|Molecular Weight||397.6 Da|
|Physical State||Yellow powder|
|Solubility||DMSO (20 mg/mL)|
|Storage||4°C, (-20°C Long term). Store solutions at -20°C for
up to one week. Protect from light. The product can be shipped at room temperature.