SI9639: LDN-57444, DUB inhibitor




LDN-57444 is a cell permeable ubiquitin C-terminal hydrolase (UCH-L1) inhibitor (Ki=0.4 µM) with approximately 28-fold greater selectivity over UCH-L3. Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis and causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. LDN-57444 is a useful tool to study UCH-L1 in different pathological conditions such as cancer and neurodegeneration.


Purity > 98% (TLC); NMR (Conforms)
Quantity 10 mg, 50 mg
Molecular Weight 397.6 Da
Physical State Yellow powder
Solubility DMSO (20 mg/mL)
CAS No. 668467-91-2
Storage 4°C, (-20°C Long term). Store solutions at -20°C for
up to one week. Protect from light. The product can be shipped at room temperature.

Additional information


10 mg, 50 mg


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  • Inhibition of ubiquitin C-terminal hydrolase
  • Cell biology
  • Drug discovery
  • Benefits: cell-permeable