Vinblastine sulfate is a semisynthetic alkaloidal anticancer agent. It induces cell cycle arrest at G2/M phase by inhibiting mitotic spindle formation. It also inhibits normal microtubule assembly and induces aberrant tubulin polymerization. Vinblastine sulfate induces apoptosis in a variety of cell lines, inhibits autophagosome maturation, and palmitoylation of tubulin. Vinblastine sulfate also suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay.
|Purity||98% by TLC|
|Quantity||5 mg, 25 mg|
|Molecular Weight||909.1 g/mol|
|Physical State||Lyophilized white crystalline powder|
|Solubility||25 mg/mL in DMSO; 50 mg/mL in water|
|Storage||-20°C, avoid freeze/thaw cycles|