SI9649: 1,10 phenanthroline

1,10-phenanthroline (o-phenanthroline) is a chelator with a high affinity for divalent metal ions.  While not specific for DUBs, it has been shown to be a potent inhibitor of JAMM-type isopeptidases through chelation of the active site Zn2+ ion.  As such, o-phenanthroline is widely used when preparing cell lysates for the enrichment of proteins bearing K63-linked polyubiquitin chains which are especially sensitive to DUBs in the JAMM family.

Info

Purity	> 99% (TLC), NMR (conforms)
Quantity	0.5 mL DMSO solution, 100X
Molecular Weight	198.21 Da
Physical State	Liquid
Solubility	DMSO
CAS No.	5144-89-8
Storage	-80°C. The Product can be shipped at room temperature.

This product has been cited 1 time.