Specifications
Encoded by the PARK2 gene, the E3 ligase Parkin is part of the multi-protein E3 complex that encodes substrate proteins for degradation in the Ubiquitin-Proteasome Pathway. The precise function of this protein is unknown; however, mutations in this gene are known to cause a familial form of Parkinson’s disease known as autosomal recessive juvenile Parkinson’s disease (AR-JP). Parkin is described to be necessary for mitophagy (autophagy of mitochondria).The R334C mutation is shown to be a hyperactive variant, enhancing Parkin activity, and is classified as likely benign based on clinical evidence.
Info
| Species | Human |
| Source | E. coli |
| Tag | His10-SUMO |
| Molecular Weight | 64 kDa |
| Quantity | 25 µg |
| Concentration | Variable |
| Formulation | 50 mM Tris pH 7.5, 150 mM NaCl, 10% Glycerol |
| Storage | -80°C, avoid freeze/thaw cycles |
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