UB320: Parkin R275W Mutant E3 Ligase

SKU: UB-0320-0025 Category:

Specifications

Encoded by the PARK2 gene, the E3 ligase Parkin is part of the multi-protein E3 complex that encodes substrate proteins for degradation in the Ubiquitin-Proteasome Pathway. The precise function of this protein is unknown; however, mutations in this gene are known to cause a familial form of Parkinson’s disease known as autosomal recessive juvenile Parkinson’s disease (AR-JP). Parkin is described to be necessary for mitophagy (autophagy of mitochondria). The R275W mutation has been shown to destabilize Parkin and disrupt interaction with the helix that mediates pUb binding.

Species Human
Source E. coli
Tag His10-SUMO
Molecular Weight 64 kDa
Quantity 25 µg
Concentration Variable
Formulation 20 mM Tris pH 7.5, 150 mM NaCl, 10% Glycerol
Storage -80°C, avoid freeze/thaw cycles

 

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