Specifications
K6-linked ubiquitination is traditionally associated with mitophagy and also a main contributor to the DNA damage response. These chain types are also involved in protein stabilization and other non-degradative processes. Phospho-ubiquitin chains represent a specialized class of polyubiquitin characterized by phosphorylation at Serine 65 and play a central role in mitophagy signaling pathways. K6 Tri-Ubiquitin (phosphorylated) is a trimeric chain of wild-type ubiquitin, wherein ubiquitin monomers are enzymatically linked together via an isopeptide bond between Lysine 6 and the C-terminal Glycine. The chains are then enzymatically phosphorylated at the Ser65 position.
| Species | Human |
| Source | E. coli |
| Tag | None |
| Molecular Weight | 25766-25926 Da (depending on degree of phosphorylation) |
| Quantity | Variable |
| Concentration | Variable |
| Formulation | 20 mM Tris pH 7.5, 150 mM NaCl |
| Storage | -80°C, avoid freeze/thaw cycles |
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